Bruton tyrosine kinase
E255805
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
All labels observed (3)
| Label | Occurrences |
|---|---|
| BTK gene | 1 |
| Bruton tyrosine kinase canonical | 1 |
| Tec family kinases | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2315778 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Bruton tyrosine kinase Context triple: [Imbruvica, targets, Bruton tyrosine kinase]
-
A.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
B.
Behring
Behring is a German surname most notably associated with Emil Adolf von Behring, the pioneering physiologist and first Nobel laureate in Physiology or Medicine for his work on serum therapy.
-
C.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
D.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
-
E.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Bruton tyrosine kinase Target entity description: Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
A.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
B.
Behring
Behring is a German surname most notably associated with Emil Adolf von Behring, the pioneering physiologist and first Nobel laureate in Physiology or Medicine for his work on serum therapy.
-
C.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
D.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
-
E.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
- F. None of above. chosen
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
non-receptor tyrosine kinase ⓘ protein ⓘ signaling molecule ⓘ |
| activatedBy |
B cell receptor engagement
ⓘ
Src family kinases ⓘ |
| associatedWithDisease |
non-Hodgkin lymphoma
ⓘ
surface form:
Waldenström macroglobulinemia
X-linked agammaglobulinemia ⓘ autoimmune diseases ⓘ chronic lymphocytic leukemia ⓘ diffuse large B-cell lymphoma ⓘ mantle cell lymphoma ⓘ |
| belongsToFamily |
Bruton tyrosine kinase
self-linksurface differs
ⓘ
surface form:
Tec family kinases
|
| containsDomain |
Pleckstrin homology domain
ⓘ
SH2 domain ⓘ SH3 domain ⓘ Tec homology domain ⓘ tyrosine kinase domain ⓘ |
| encodedByGene |
Bruton tyrosine kinase
self-linksurface differs
ⓘ
surface form:
BTK gene
|
| expressedInCellType |
B lymphocytes
ⓘ
surface form:
B lymphocyte
mast cell ⓘ myeloid cell ⓘ platelet ⓘ |
| expressedInTissue |
bone marrow
ⓘ
lymph node ⓘ spleen ⓘ |
| hasAbbreviation | BTK ⓘ |
| hasAlternativeName |
BTK
ⓘ
surface form:
BTK tyrosine kinase
|
| hasBiologicalProcess |
B cell activation
ⓘ
B cell development ⓘ B cell differentiation ⓘ B cell receptor signaling pathway ⓘ MAPK cascade activation ⓘ NF-κB activation ⓘ calcium signaling in B cells ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
protein tyrosine kinase activity ⓘ |
| hasRoleInImmunity |
humoral immune response
ⓘ
innate immune signaling ⓘ |
| inhibitedBy |
covalent BTK inhibitors
ⓘ
non-covalent BTK inhibitors ⓘ |
| isTherapeuticTargetOf |
acalabrutinib
ⓘ
Imbruvica ⓘ
surface form:
ibrutinib
other BTK inhibitors ⓘ pirtobrutinib ⓘ zanubrutinib ⓘ |
| locatedOnChromosome | X chromosome ⓘ |
| mutationConsequence |
loss-of-function mutations cause B cell maturation arrest
ⓘ
loss-of-function mutations cause hypogammaglobulinemia ⓘ |
| namedAfter | Ogden Bruton ⓘ |
| participatesInPathway |
B cell receptor signaling pathway
ⓘ
Fc receptor signaling pathway ⓘ Toll-like receptor signaling pathway ⓘ chemokine signaling pathway ⓘ |
| phosphorylates |
BTK substrates in BCR pathway
ⓘ
PLCγ2 ⓘ |
| regulates |
B cell proliferation
ⓘ
B cell survival ⓘ antibody production ⓘ |
| subcellularLocation |
cell periphery
ⓘ
cytoplasm ⓘ plasma membrane ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Bruton tyrosine kinase Description of subject: Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
BTK gene
this entity surface form:
Tec family kinases