Triple
T10837751
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | Bruton tyrosine kinase |
E255805
|
entity |
| Predicate | phosphorylates |
P34126
|
FINISHED |
| Object |
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
|
E888597
|
NE FINISHED |
How this triple was built (5 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: PLCγ2 | Statement: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: PLCγ2 Context triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
-
A.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
-
B.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
C.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
D.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
E.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg
Description generation
gpt-5.1
Instruction
Generate a one-sentence description of the target entity. You are given a context triple in the form (subject, predicate, object), where the object is the target entity. # Instructions Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. Avoid repeating the information from the triple, unless really essential. # Response Format Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: PLCγ2 Triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
Generated description
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: PLCγ2 Target entity description: PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
A.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
-
B.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
C.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
D.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
E.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
- F. None of above. chosen
PD
Predicate disambiguation
gpt-5-mini-2025-08-07
Target predicate: phosphorylates Context triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
-
A.
hasPostTranslationalModification
Indicates that a biomolecule has undergone a specific chemical modification after its initial synthesis (translation), altering its structure or function.
-
B.
modulates
chosen
Indicates that one entity adjusts, regulates, or alters the intensity, frequency, or effect of another entity or process.
-
C.
isMetabolizedBy
Indicates that a substance is biochemically broken down or transformed through metabolic processes carried out by a specified organism, cell type, or enzyme system.
-
D.
phase
Indicates that one entity is in a particular stage, step, or phase within a process, sequence, or lifecycle relative to another reference.
-
E.
passes
Indicates that one entity successfully transfers, hands over, or moves something (such as an object, message, or responsibility) to another entity.
- F. None of above.
Provenance (6 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69d6aa81a5d08190aa86689061d1ddd2 |
completed | April 8, 2026, 7:20 p.m. |
| NER | Named-entity recognition | batch_69d747002b3081908726901ee83d8f38 |
completed | April 9, 2026, 6:28 a.m. |
| NED1 | Entity disambiguation (via context triple) | batch_69deb139072081908a67e76a83575c32 |
completed | April 14, 2026, 9:27 p.m. |
| NEDg | Description generation | batch_69deb41c9ae881909a3dab1292d6ddd7 |
completed | April 14, 2026, 9:39 p.m. |
| NED2 | Entity disambiguation (via description) | batch_69deb4e471648190a00f3a921b5fb657 |
completed | April 14, 2026, 9:43 p.m. |
| PD | Predicate disambiguation | batch_69d70d25280c8190b648d7d1958b413a |
completed | April 9, 2026, 2:21 a.m. |
Created at: April 8, 2026, 9:19 p.m.