Triple

T10837751
Position Surface form Disambiguated ID Type / Status
Subject Bruton tyrosine kinase E255805 entity
Predicate phosphorylates P34126 FINISHED
Object PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
E888597 NE FINISHED

How this triple was built (5 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: PLCγ2 | Statement: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: PLCγ2
Context triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
  • A. Ezrin
    Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
  • B. Bruton tyrosine kinase
    Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
  • C. Gi protein
    Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
  • D. PKC
    PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
  • E. PKC
    PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: PLCγ2
Triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
Generated description
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: PLCγ2
Target entity description: PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
  • A. Ezrin
    Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
  • B. Bruton tyrosine kinase
    Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
  • C. Gi protein
    Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
  • D. PKC
    PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
  • E. PKC
    PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
  • F. None of above. chosen
PD Predicate disambiguation gpt-5-mini-2025-08-07
Target predicate: phosphorylates
Context triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
  • A. hasPostTranslationalModification
    Indicates that a biomolecule has undergone a specific chemical modification after its initial synthesis (translation), altering its structure or function.
  • B. modulates chosen
    Indicates that one entity adjusts, regulates, or alters the intensity, frequency, or effect of another entity or process.
  • C. isMetabolizedBy
    Indicates that a substance is biochemically broken down or transformed through metabolic processes carried out by a specified organism, cell type, or enzyme system.
  • D. phase
    Indicates that one entity is in a particular stage, step, or phase within a process, sequence, or lifecycle relative to another reference.
  • E. passes
    Indicates that one entity successfully transfers, hands over, or moves something (such as an object, message, or responsibility) to another entity.
  • F. None of above.

Provenance (6 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d6aa81a5d08190aa86689061d1ddd2 completed April 8, 2026, 7:20 p.m.
NER Named-entity recognition batch_69d747002b3081908726901ee83d8f38 completed April 9, 2026, 6:28 a.m.
NED1 Entity disambiguation (via context triple) batch_69deb139072081908a67e76a83575c32 completed April 14, 2026, 9:27 p.m.
NEDg Description generation batch_69deb41c9ae881909a3dab1292d6ddd7 completed April 14, 2026, 9:39 p.m.
NED2 Entity disambiguation (via description) batch_69deb4e471648190a00f3a921b5fb657 completed April 14, 2026, 9:43 p.m.
PD Predicate disambiguation batch_69d70d25280c8190b648d7d1958b413a completed April 9, 2026, 2:21 a.m.
Created at: April 8, 2026, 9:19 p.m.