PLCγ2
E888597
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
Statements (64)
| Predicate | Object |
|---|---|
| instanceOf |
phospholipase C isoform
ⓘ
protein ⓘ signal transduction protein ⓘ |
| activatedBy |
B cell receptor
NERFINISHED
ⓘ
Bruton tyrosine kinase NERFINISHED ⓘ Fcγ receptor NERFINISHED ⓘ Fcε receptor NERFINISHED ⓘ GPVI collagen receptor NERFINISHED ⓘ Syk tyrosine kinase NERFINISHED ⓘ |
| alternativeName |
PLC-gamma-2
NERFINISHED
ⓘ
PLCG2 NERFINISHED ⓘ phospholipase C gamma 2 NERFINISHED ⓘ |
| associatedWith |
Alzheimer’s disease risk modulation
ⓘ
PLCG2-associated antibody deficiency and immune dysregulation ⓘ autoinflammatory disease ⓘ familial cold autoinflammatory syndrome 3 NERFINISHED ⓘ immune deficiency ⓘ |
| biologicalProcess |
B cell receptor signaling pathway
ⓘ
Fc receptor signaling pathway ⓘ bone resorption ⓘ calcium ion mobilization ⓘ immune response ⓘ intracellular signal transduction ⓘ lymphocyte activation ⓘ mast cell activation ⓘ myeloid cell activation ⓘ natural killer cell activation ⓘ neutrophil activation ⓘ osteoclast differentiation ⓘ phosphoinositide signaling ⓘ platelet activation ⓘ receptor-mediated signaling ⓘ regulation of cytosolic calcium ion concentration ⓘ |
| catalyzes | hydrolysis of phosphatidylinositol 4,5-bisphosphate ⓘ |
| containsDomain |
C2 domain
ⓘ
EF-hand domain ⓘ PH domain ⓘ SH2 domain ⓘ SH3 domain ⓘ X catalytic domain ⓘ Y catalytic domain ⓘ |
| encodedBy | PLCG2 gene NERFINISHED ⓘ |
| expressedIn |
B cells
ⓘ
NK cells NERFINISHED ⓘ mast cells ⓘ myeloid cells ⓘ platelets ⓘ |
| hasEnzymeCommissionNumber | EC 3.1.4.11 ⓘ |
| locatedIn |
cytoplasm
ⓘ
plasma membrane ⓘ |
| molecularFunction |
SH2 domain binding
ⓘ
SH3 domain binding ⓘ calcium ion binding ⓘ phosphatidylinositol binding ⓘ phosphatidylinositol phospholipase C activity ⓘ phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity ⓘ phospholipase C activity ⓘ |
| organism | Homo sapiens ⓘ |
| orthologOf | mouse Plcg2 ⓘ |
| produces |
diacylglycerol
ⓘ
inositol 1,4,5-trisphosphate ⓘ |
| upstreamOf |
MAPK cascade activation
ⓘ
NF-κB activation ⓘ protein kinase C activation ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.