Src family kinases
E888596
Src family kinases are a group of non-receptor tyrosine kinases that regulate key cellular processes such as proliferation, differentiation, survival, and migration, and are often implicated in cancer and immune signaling.
Statements (87)
| Predicate | Object |
|---|---|
| instanceOf |
non-receptor tyrosine kinase family
ⓘ
protein family ⓘ |
| associatedWith |
autoimmune diseases
ⓘ
bone resorption ⓘ cancer ⓘ inflammatory diseases ⓘ leukemia ⓘ lymphoma ⓘ osteoporosis ⓘ solid tumors ⓘ |
| biologicalProcess |
B cell receptor signaling pathway
ⓘ
T cell receptor signaling pathway ⓘ cell adhesion ⓘ cell differentiation ⓘ cell migration ⓘ cell proliferation ⓘ cell survival ⓘ cytoskeletal organization ⓘ growth factor receptor signaling pathway ⓘ immune receptor signaling pathway ⓘ integrin-mediated signaling pathway ⓘ signal transduction ⓘ |
| catalyzes | protein tyrosine phosphorylation ⓘ |
| cellularLocation |
cytoplasm
ⓘ
perinuclear region ⓘ plasma membrane ⓘ |
| discoveredIn | context of Rous sarcoma virus research ⓘ |
| evolutionarilyConservedIn |
metazoans
ⓘ
vertebrates ⓘ |
| hasConservedMotif |
DFG motif in activation loop
GENERATED
ⓘ
HRD motif in catalytic loop GENERATED ⓘ |
| hasConservedResidue |
C-terminal regulatory tyrosine residue
GENERATED
ⓘ
catalytic lysine in kinase domain GENERATED ⓘ |
| hasDomain |
C-terminal regulatory tail
ⓘ
N-terminal myristoylation motif ⓘ SH2 domain ⓘ SH3 domain ⓘ protein tyrosine kinase domain ⓘ unique N-terminal region ⓘ |
| hasMember |
BLK
NERFINISHED
ⓘ
BRK NERFINISHED ⓘ CHK NERFINISHED ⓘ CSK NERFINISHED ⓘ FGR NERFINISHED ⓘ FRK NERFINISHED ⓘ FYN NERFINISHED ⓘ HCK NERFINISHED ⓘ LCK NERFINISHED ⓘ LYN NERFINISHED ⓘ MATK ⓘ PTK6 NERFINISHED ⓘ SRC NERFINISHED ⓘ SRMS NERFINISHED ⓘ YES1 NERFINISHED ⓘ YRK ⓘ |
| inhibitedBy |
PP2 (experimental inhibitor)
ⓘ
SU6656 (experimental inhibitor) ⓘ bosutinib NERFINISHED ⓘ dasatinib NERFINISHED ⓘ ponatinib ⓘ saracatinib NERFINISHED ⓘ |
| molecularFunction |
ATP binding
ⓘ
non-receptor protein tyrosine kinase activity ⓘ |
| nameDerivedFrom | Rous sarcoma virus Src oncogene NERFINISHED ⓘ |
| pathwayInvolvement |
EGFR signaling pathway
ⓘ
PDGFR signaling pathway ⓘ VEGFR signaling pathway ⓘ adaptive immune signaling pathways ⓘ focal adhesion signaling pathway ⓘ innate immune signaling pathways ⓘ oncogenic signaling pathways ⓘ platelet activation pathways ⓘ |
| positivelyRegulates |
MAPK signaling pathway
ⓘ
PI3K-AKT signaling pathway NERFINISHED ⓘ RAS signaling pathway ⓘ |
| postTranslationalModification |
N-terminal myristoylation
ⓘ
N-terminal palmitoylation (subset of members) ⓘ serine/threonine phosphorylation ⓘ tyrosine phosphorylation ⓘ |
| regulatedBy |
C-terminal Src kinase
NERFINISHED
ⓘ
CSK NERFINISHED ⓘ SH2 domain intramolecular interaction ⓘ SH3 domain intramolecular interaction ⓘ binding of activated receptors ⓘ phosphorylation of C-terminal tyrosine ⓘ protein tyrosine phosphatases NERFINISHED ⓘ |
| subClassOf | tyrosine kinase family ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.