Triple

Target class: non-receptor tyrosine kinase family
Context triple: [Src family kinases, instanceOf, non-receptor tyrosine kinase family]

• A. receptor tyrosine kinase
  A receptor tyrosine kinase is a transmembrane protein that, upon binding an extracellular ligand, dimerizes and autophosphorylates its intracellular tyrosine residues to initiate intracellular signaling cascades regulating cell growth, differentiation, and survival.
• B. tyrosine kinase inhibitor
  A tyrosine kinase inhibitor is a drug that blocks the activity of tyrosine kinases—enzymes involved in cell signaling pathways—to prevent uncontrolled cell growth and proliferation, commonly used in cancer therapy.
• C. Bruton’s tyrosine kinase chosen
  Bruton’s tyrosine kinase is a non-receptor tyrosine kinase crucial for B-cell receptor signaling, development, and function, and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
• D. G protein alpha subunit family
  The G protein alpha subunit family comprises the guanine nucleotide-binding protein α subunits that couple cell surface receptors to intracellular signaling pathways by cycling between inactive GDP-bound and active GTP-bound states.
• E. cyclin-dependent kinase
  A cyclin-dependent kinase is an enzyme that regulates progression through the cell cycle by phosphorylating specific target proteins in a manner dependent on binding to cyclins.
• F. None of above.