chronic lymphocytic leukemia
E822402
Chronic lymphocytic leukemia is a slow-growing cancer of the blood and bone marrow characterized by an overproduction of abnormal lymphocytes, most commonly affecting older adults.
All labels observed (1)
| Label | Occurrences |
|---|---|
| chronic lymphocytic leukemia canonical | 4 |
How this entity was disambiguated
This entity first appeared as the object of triple T9807078 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: chronic lymphocytic leukemia Context triple: [MabThera, indication, chronic lymphocytic leukemia]
-
A.
CLL
CLL is the IATA airport code for Easterwood Airport, a regional airport serving College Station, Texas.
-
B.
non-Hodgkin lymphoma
Non-Hodgkin lymphoma is a diverse group of blood cancers that originate in the lymphatic system from abnormal lymphocytes and can vary widely in aggressiveness and prognosis.
-
C.
Hodgkin lymphoma
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, characterized by the presence of abnormal Reed–Sternberg cells and often affecting lymph nodes.
-
D.
Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
-
E.
Leukemia and Lymphoma Research
Leukemia and Lymphoma Research is a UK-based medical research charity dedicated to improving the diagnosis, treatment, and prevention of blood cancers such as leukemia and lymphoma.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: chronic lymphocytic leukemia Target entity description: Chronic lymphocytic leukemia is a slow-growing cancer of the blood and bone marrow characterized by an overproduction of abnormal lymphocytes, most commonly affecting older adults.
-
A.
CLL
CLL is the IATA airport code for Easterwood Airport, a regional airport serving College Station, Texas.
-
B.
non-Hodgkin lymphoma
Non-Hodgkin lymphoma is a diverse group of blood cancers that originate in the lymphatic system from abnormal lymphocytes and can vary widely in aggressiveness and prognosis.
-
C.
Hodgkin lymphoma
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, characterized by the presence of abnormal Reed–Sternberg cells and often affecting lymph nodes.
-
D.
Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
-
E.
Leukemia and Lymphoma Research
Leukemia and Lymphoma Research is a UK-based medical research charity dedicated to improving the diagnosis, treatment, and prevention of blood cancers such as leukemia and lymphoma.
- F. None of above. chosen
Statements (64)
| Predicate | Object |
|---|---|
| instanceOf |
hematologic malignancy
ⓘ
leukemia ⓘ lymphoproliferative disorder ⓘ non-Hodgkin lymphoma ⓘ |
| affectsCellType | B lymphocyte NERFINISHED ⓘ |
| affectsSystem |
blood
ⓘ
bone marrow ⓘ |
| associatedWithGeneMutation |
NOTCH1 mutation
GENERATED
ⓘ
SF3B1 mutation GENERATED ⓘ TP53 mutation GENERATED ⓘ |
| associatedWithGeneticAbnormality |
del(11q)
GENERATED
ⓘ
del(13q14) GENERATED ⓘ del(17p) GENERATED ⓘ trisomy 12 GENERATED ⓘ |
| canBe | asymptomatic at diagnosis ⓘ |
| canTransformTo | diffuse large B-cell lymphoma ⓘ |
| commonLaboratoryFinding |
absolute lymphocytosis
ⓘ
anemia ⓘ thrombocytopenia ⓘ |
| commonSign |
hepatomegaly
ⓘ
lymphadenopathy ⓘ splenomegaly ⓘ |
| commonSymptom |
fatigue
ⓘ
night sweats ⓘ recurrent infections ⓘ unintentional weight loss ⓘ |
| complication |
autoimmune hemolytic anemia
ⓘ
hypogammaglobulinemia ⓘ immune thrombocytopenia ⓘ increased infection risk ⓘ |
| diagnosedBy |
complete blood count
ⓘ
flow cytometry immunophenotyping ⓘ peripheral blood smear ⓘ |
| epidemiologyRegion | most common leukemia in Western countries ⓘ |
| hasAbbreviation | CLL NERFINISHED ⓘ |
| hasFullName | chronic lymphocytic leukemia ⓘ |
| hasICD10Code | C91.1 ⓘ |
| hasImmunophenotypeMarker |
CD19
NERFINISHED
ⓘ
CD20 dim ⓘ CD23 NERFINISHED ⓘ CD5-positive B cells ⓘ surface immunoglobulin dim ⓘ |
| hasPrognosticMarker |
IGHV mutation status
ⓘ
TP53 disruption ⓘ beta-2 microglobulin level ⓘ |
| isCharacterizedBy |
accumulation of monoclonal B cells
ⓘ
bone marrow infiltration ⓘ lymph node enlargement ⓘ lymphocytosis ⓘ slow progression ⓘ |
| mayRequire | bone marrow biopsy ⓘ |
| primaryTreatmentOption | watchful waiting GENERATED ⓘ |
| riskFactor |
advanced age
ⓘ
family history of CLL ⓘ |
| sexPredominance | more common in males ⓘ |
| transformationSyndromeName | Richter transformation NERFINISHED ⓘ |
| treatmentOption |
BCL2 inhibitor
ⓘ
Bruton tyrosine kinase inhibitor ⓘ allogeneic stem cell transplantation ⓘ anti-CD20 monoclonal antibody ⓘ chemoimmunotherapy ⓘ |
| typicalCourse | indolent ⓘ |
| typicalOnsetAge | >=60 years GENERATED ⓘ |
| typicalOnsetAgeGroup | older adults GENERATED ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: chronic lymphocytic leukemia Description of subject: Chronic lymphocytic leukemia is a slow-growing cancer of the blood and bone marrow characterized by an overproduction of abnormal lymphocytes, most commonly affecting older adults.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.