MabThera
E238179
MabThera is Roche’s brand name for rituximab, a monoclonal antibody used primarily to treat certain types of blood cancers and autoimmune diseases.
All labels observed (1)
| Label | Occurrences |
|---|---|
| MabThera canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T2138513 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: MabThera Context triple: [Roche, product, MabThera]
-
A.
Lady of Terror
Lady of Terror is an epithet of the Egyptian goddess Sekhmet, highlighting her fearsome power as a lioness deity of war, destruction, and divine retribution.
-
B.
The Mangler
The Mangler is a horror short story by Stephen King about a possessed industrial laundry machine that becomes the source of gruesome deaths.
-
C.
The Cannibal
The Cannibal is the legendary Belgian cyclist Eddy Merckx, renowned for his relentless, all-conquering racing style and status as one of the greatest cyclists in history.
-
D.
The Monster
The Monster is the stage name and alter ego of American record producer and rapper Swizz Beatz, under which he has released music and production work.
-
E.
Vampirina
Vampirina is an animated Disney Junior television series that follows a young vampire girl adjusting to life in the human world after moving from Transylvania to Pennsylvania.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: MabThera Target entity description: MabThera is Roche’s brand name for rituximab, a monoclonal antibody used primarily to treat certain types of blood cancers and autoimmune diseases.
-
A.
Lady of Terror
Lady of Terror is an epithet of the Egyptian goddess Sekhmet, highlighting her fearsome power as a lioness deity of war, destruction, and divine retribution.
-
B.
The Mangler
The Mangler is a horror short story by Stephen King about a possessed industrial laundry machine that becomes the source of gruesome deaths.
-
C.
The Cannibal
The Cannibal is the legendary Belgian cyclist Eddy Merckx, renowned for his relentless, all-conquering racing style and status as one of the greatest cyclists in history.
-
D.
The Monster
The Monster is the stage name and alter ego of American record producer and rapper Swizz Beatz, under which he has released music and production work.
-
E.
Vampirina
Vampirina is an animated Disney Junior television series that follows a young vampire girl adjusting to life in the human world after moving from Transylvania to Pennsylvania.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
biopharmaceutical drug
ⓘ
monoclonal antibody ⓘ rituximab-containing medicinal product ⓘ |
| ATCCode | L01XC02 ⓘ |
| belongsToPortfolioOf |
Roche
ⓘ
surface form:
Roche oncology products
|
| bindsTo | CD20-positive B lymphocytes ⓘ |
| commonAdverseEffect |
hypogammaglobulinemia
ⓘ
infections ⓘ infusion-related reactions ⓘ neutropenia ⓘ |
| contraindication |
severe active infections
ⓘ
severe heart failure ⓘ |
| hasActiveIngredient | rituximab ⓘ |
| hasBrandOwner | Roche ⓘ |
| hasDosageForm |
concentrate for solution for infusion
ⓘ
solution for subcutaneous injection ⓘ |
| hasDrugClass |
anti-CD20 monoclonal antibody
ⓘ
antineoplastic agent ⓘ immunosuppressive agent ⓘ |
| hasEquivalentProduct | Rituxan ⓘ |
| hasInternationalNonproprietaryName |
Rituxan
ⓘ
surface form:
rituximab
|
| hasManufacturer |
Roche
ⓘ
surface form:
F. Hoffmann-La Roche AG
|
| hasMolecularTarget | B cells ⓘ |
| hasMolecularType | chimeric monoclonal antibody ⓘ |
| indication |
certain autoimmune diseases
ⓘ
chronic lymphocytic leukemia ⓘ diffuse large B-cell lymphoma ⓘ follicular lymphoma ⓘ granulomatosis with polyangiitis ⓘ microscopic polyangiitis ⓘ non-Hodgkin lymphoma ⓘ rheumatoid arthritis ⓘ |
| isBrandNameOf | rituximab ⓘ |
| isMarketedAs | MabThera SC for subcutaneous formulation ⓘ |
| isUsedFor |
treatment of certain autoimmune diseases
ⓘ
treatment of certain blood cancers ⓘ |
| mechanismOfAction |
induces B-cell depletion
ⓘ
mediates antibody-dependent cellular cytotoxicity ⓘ mediates complement-dependent cytotoxicity ⓘ |
| regulatoryRegion | Europe ⓘ |
| requiresMonitoringOf |
complete blood count
ⓘ
hepatitis B virus reactivation ⓘ |
| routeOfAdministration |
intravenous infusion
ⓘ
subcutaneous injection ⓘ |
| targets |
CD20 protein
ⓘ
surface form:
CD20 antigen
|
| usedInCombinationWith |
chemotherapy
ⓘ
methotrexate ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: MabThera Description of subject: MabThera is Roche’s brand name for rituximab, a monoclonal antibody used primarily to treat certain types of blood cancers and autoimmune diseases.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.