CD20 protein

E261827
B‑cell marker cell surface antigen drug target membrane protein

CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.

Try in SPARQL Jump to: Surface forms Statements Referenced by

All labels observed (5)

Label Occurrences
CD20 antigen 3
B‑lymphocyte antigen CD20 1
CD20 1

Statements (49)

Predicate Object
instanceOf B‑cell marker ⓘ
cell surface antigen ⓘ
drug target ⓘ
membrane protein ⓘ
alternativeName B1 antigen ⓘ
Bp35 ⓘ
CD20 protein ⓘ
surface form: B‑lymphocyte antigen CD20

CD20 protein ⓘ
surface form: LEU‑16 antigen
belongsToFamily membrane‑spanning 4‑domains subfamily A (MS4A) ⓘ
biologicalProcess B‑cell activation ⓘ
B‑cell differentiation ⓘ
B‑cell proliferation ⓘ
regulation of calcium ion transport ⓘ
cellularLocation plasma membrane ⓘ
encodedBy MS4A1 gene ⓘ
expressedIn human immune system ⓘ
lymph nodes ⓘ
peripheral blood B cells ⓘ
spleen B cells ⓘ
foundIn B lymphocyte membrane ⓘ
mature B cells ⓘ
pre‑B cells ⓘ
hasTransmembraneDomains 4 ⓘ
molecularFunction B‑cell receptor signaling modulator ⓘ
calcium ion channel regulator activity ⓘ
notExpressedIn hematopoietic stem cells ⓘ
normal plasma cells ⓘ
pro‑B cells ⓘ
organism Homo sapiens ⓘ
postTranslationalModification glycosylation ⓘ
recognizedBy anti‑CD20 monoclonal antibodies ⓘ
targetOf mosunetuzumab (bispecific antibody component) ⓘ
Rituxan ⓘ
surface form: obinutuzumab

ocrelizumab ⓘ
Ofatumumab ⓘ
surface form: ofatumumab

Ofatumumab ⓘ
surface form: ofatumumab (autoimmune indications)

Rituxan ⓘ
surface form: rituximab
therapeuticArea B‑cell non‑Hodgkin lymphoma ⓘ
chronic lymphocytic leukemia ⓘ
granulomatosis with polyangiitis ⓘ
microscopic polyangiitis ⓘ
multiple sclerosis ⓘ
pemphigus vulgaris ⓘ
rheumatoid arthritis ⓘ
topology multi‑pass transmembrane protein ⓘ
usedAs diagnostic marker for B‑cell leukemias ⓘ
diagnostic marker for B‑cell lymphomas ⓘ
usedIn immunohistochemistry of lymphoid tissues ⓘ
immunophenotyping of B cells by flow cytometry ⓘ

Referenced by (7)

Full triples — surface form annotated when it differs from this entity's canonical label.

Rituxan → targets → CD20 protein ⓘ
MabThera → targets → CD20 protein ⓘ
this entity surface form: CD20 antigen
CD20 protein → alternativeName → CD20 protein ⓘ
this entity surface form: B‑lymphocyte antigen CD20
CD20 protein → alternativeName → CD20 protein ⓘ
this entity surface form: LEU‑16 antigen
B lymphocytes → express → CD20 protein ⓘ
this entity surface form: CD20
Ruxience → targets → CD20 protein ⓘ
this entity surface form: CD20 antigen
Riabni → hasTarget → CD20 protein ⓘ
this entity surface form: CD20 antigen