Triple

T11074399
Position Surface form Disambiguated ID Type / Status
Subject CD20 protein E261827 entity
Predicate encodedBy P14248 FINISHED
Object MS4A1 gene
The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
E902882 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: MS4A1 gene | Statement: [CD20 protein, encodedBy, MS4A1 gene]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: MS4A1 gene
Context triple: [CD20 protein, encodedBy, MS4A1 gene]
  • A. HTT gene
    The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
  • B. APOE gene
    The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
  • C. GNAS
    GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
  • D. GNAI2 gene (for Gαi2 in humans)
    The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
  • E. CD46
    CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: MS4A1 gene
Triple: [CD20 protein, encodedBy, MS4A1 gene]
Generated description
The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: MS4A1 gene
Target entity description: The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
  • A. HTT gene
    The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
  • B. APOE gene
    The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
  • C. GNAS
    GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
  • D. GNAI2 gene (for Gαi2 in humans)
    The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
  • E. CD46
    CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d6aa9983c08190b0ef61603b69feac completed April 8, 2026, 7:20 p.m.
NER Named-entity recognition batch_69d7994e32fc8190a6591d9e82b68f75 completed April 9, 2026, 12:19 p.m.
NED1 Entity disambiguation (via context triple) batch_69e3c8cc77988190aad54f56dbd0f8cf completed April 18, 2026, 6:09 p.m.
NEDg Description generation batch_69e3cefc00148190a1850dc6e31523c3 completed April 18, 2026, 6:35 p.m.
NED2 Entity disambiguation (via description) batch_69e3d014a644819092c76aa02b573ca9 completed April 18, 2026, 6:40 p.m.
Created at: April 8, 2026, 9:26 p.m.