MS4A1 gene
E902882
The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| MS4A1 | 0 |
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein-coding gene ⓘ |
| associatedWithDisease |
B-cell non-Hodgkin lymphoma
ⓘ
autoimmune diseases ⓘ chronic lymphocytic leukemia NERFINISHED ⓘ diffuse large B-cell lymphoma ⓘ follicular lymphoma NERFINISHED ⓘ |
| encodes |
B-lymphocyte antigen CD20
NERFINISHED
ⓘ
CD20 NERFINISHED ⓘ membrane-spanning 4-domains subfamily A member 1 protein NERFINISHED ⓘ |
| expressedInCellType |
B lymphocyte
NERFINISHED
ⓘ
pre-B cell ⓘ |
| expressedInTissue |
lymph node
ⓘ
lymphoid tissue ⓘ spleen ⓘ |
| geneType | protein coding ⓘ |
| hasAlternativeName |
B1
ⓘ
CD20 NERFINISHED ⓘ membrane-spanning 4-domains A1 NERFINISHED ⓘ |
| hasBiologicalProcess |
B cell activation
ⓘ
B cell proliferation ⓘ regulation of humoral immune response ⓘ |
| hasCellularComponent |
external side of plasma membrane
ⓘ
integral component of membrane ⓘ plasma membrane ⓘ |
| hasClinicalUse |
diagnostic marker for B-cell lymphomas
ⓘ
therapeutic target in autoimmune disease ⓘ |
| hasMolecularFunction |
CD20 receptor activity
ⓘ
calcium ion channel activity ⓘ |
| hasTransmembraneDomainCount | 4 ⓘ |
| locatedOnChromosome | chromosome 11 ⓘ |
| locatedOnChromosomeArm | 11q ⓘ |
| memberOf | MS4A gene family NERFINISHED ⓘ |
| notExpressedInCellType | plasma cell ⓘ |
| orthologInSpecies | Ms4a1 in Mus musculus ⓘ |
| participatesInPathway |
B cell receptor signaling pathway
ⓘ
calcium signaling pathway ⓘ |
| regulatedBy | B cell differentiation signals ⓘ |
| species | Homo sapiens NERFINISHED ⓘ |
| subcellularLocation |
cell surface
ⓘ
lipid raft ⓘ |
| targetOfDrug |
obinutuzumab
NERFINISHED
ⓘ
ocrelizumab ⓘ ofatumumab NERFINISHED ⓘ rituximab NERFINISHED ⓘ ublituximab NERFINISHED ⓘ |
| usedAsBiomarkerFor |
B cell depletion therapy monitoring
ⓘ
B cell malignancies ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.