MS4A1 gene
E902882
The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
All labels observed (1)
| Label | Occurrences |
|---|---|
| MS4A1 gene canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074399 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: MS4A1 gene Context triple: [CD20 protein, encodedBy, MS4A1 gene]
-
A.
HTT gene
The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
-
B.
APOE gene
The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
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C.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
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D.
GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
-
E.
CD46
CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: MS4A1 gene Target entity description: The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
-
A.
HTT gene
The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
-
B.
APOE gene
The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
-
C.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
D.
GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
-
E.
CD46
CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein-coding gene ⓘ |
| associatedWithDisease |
B-cell non-Hodgkin lymphoma
ⓘ
autoimmune diseases ⓘ chronic lymphocytic leukemia NERFINISHED ⓘ diffuse large B-cell lymphoma ⓘ follicular lymphoma NERFINISHED ⓘ |
| encodes |
B-lymphocyte antigen CD20
NERFINISHED
ⓘ
CD20 NERFINISHED ⓘ membrane-spanning 4-domains subfamily A member 1 protein NERFINISHED ⓘ |
| expressedInCellType |
B lymphocyte
NERFINISHED
ⓘ
pre-B cell ⓘ |
| expressedInTissue |
lymph node
ⓘ
lymphoid tissue ⓘ spleen ⓘ |
| geneType | protein coding ⓘ |
| hasAlternativeName |
B1
ⓘ
CD20 NERFINISHED ⓘ membrane-spanning 4-domains A1 NERFINISHED ⓘ |
| hasBiologicalProcess |
B cell activation
ⓘ
B cell proliferation ⓘ regulation of humoral immune response ⓘ |
| hasCellularComponent |
external side of plasma membrane
ⓘ
integral component of membrane ⓘ plasma membrane ⓘ |
| hasClinicalUse |
diagnostic marker for B-cell lymphomas
ⓘ
therapeutic target in autoimmune disease ⓘ |
| hasMolecularFunction |
CD20 receptor activity
ⓘ
calcium ion channel activity ⓘ |
| hasTransmembraneDomainCount | 4 ⓘ |
| locatedOnChromosome | chromosome 11 ⓘ |
| locatedOnChromosomeArm | 11q ⓘ |
| memberOf | MS4A gene family NERFINISHED ⓘ |
| notExpressedInCellType | plasma cell ⓘ |
| orthologInSpecies | Ms4a1 in Mus musculus ⓘ |
| participatesInPathway |
B cell receptor signaling pathway
ⓘ
calcium signaling pathway ⓘ |
| regulatedBy | B cell differentiation signals ⓘ |
| species | Homo sapiens NERFINISHED ⓘ |
| subcellularLocation |
cell surface
ⓘ
lipid raft ⓘ |
| targetOfDrug |
obinutuzumab
NERFINISHED
ⓘ
ocrelizumab ⓘ ofatumumab NERFINISHED ⓘ rituximab NERFINISHED ⓘ ublituximab NERFINISHED ⓘ |
| usedAsBiomarkerFor |
B cell depletion therapy monitoring
ⓘ
B cell malignancies ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: MS4A1 gene Description of subject: The MS4A1 gene is a human gene that encodes the B-cell surface molecule CD20, a key target in immunotherapy for B-cell malignancies and autoimmune diseases.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.