microscopic polyangiitis
E902884
Microscopic polyangiitis is a rare autoimmune small-vessel vasculitis that causes inflammation and damage in organs such as the kidneys, lungs, and nerves, often associated with anti-neutrophil cytoplasmic antibodies (ANCA).
Statements (60)
| Predicate | Object |
|---|---|
| instanceOf |
ANCA-associated vasculitis
ⓘ
autoimmune disease ⓘ small-vessel vasculitis ⓘ |
| affects |
arterioles
ⓘ
capillaries ⓘ small blood vessels ⓘ venules ⓘ |
| associatedWith |
MPO-ANCA
NERFINISHED
ⓘ
anti-neutrophil cytoplasmic antibodies ⓘ p-ANCA NERFINISHED ⓘ |
| bodySystemAffected |
kidneys
ⓘ
lungs ⓘ peripheral nervous system NERFINISHED ⓘ skin ⓘ |
| differentialDiagnosis |
Henoch–Schönlein purpura
NERFINISHED
ⓘ
cryoglobulinemic vasculitis ⓘ eosinophilic granulomatosis with polyangiitis NERFINISHED ⓘ granulomatosis with polyangiitis NERFINISHED ⓘ immune complex vasculitis ⓘ |
| hasCause | autoimmune reaction ⓘ |
| hasComplication |
chronic kidney disease
ⓘ
end-stage renal disease ⓘ pulmonary hemorrhage ⓘ rapidly progressive glomerulonephritis ⓘ respiratory failure ⓘ |
| hasCourse |
chronic relapsing-remitting course
ⓘ
potentially life-threatening ⓘ |
| hasDiagnosticTest |
ANCA testing
ⓘ
chest imaging ⓘ kidney biopsy ⓘ nerve or skin biopsy ⓘ urinalysis ⓘ |
| hasEpidemiology |
affects both sexes
ⓘ
affects middle-aged and older adults ⓘ |
| hasPathology |
crescentic glomerulonephritis
ⓘ
necrotizing vasculitis ⓘ pauci-immune glomerulonephritis ⓘ |
| hasSymptom |
arthralgia
ⓘ
cough ⓘ dyspnea ⓘ fatigue ⓘ fever ⓘ hematuria ⓘ hemoptysis ⓘ mononeuritis multiplex ⓘ myalgia ⓘ palpable purpura ⓘ peripheral neuropathy ⓘ proteinuria ⓘ skin purpura ⓘ weight loss ⓘ |
| medicalCondition | rare disease ⓘ |
| treatedWith |
azathioprine
ⓘ
cyclophosphamide NERFINISHED ⓘ glucocorticoids ⓘ methotrexate NERFINISHED ⓘ mycophenolate mofetil ⓘ plasmapheresis ⓘ rituximab NERFINISHED ⓘ |
| typicallyLacks | granulomatous inflammation ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.