hasContraindication
P23156
predicate
Indicates that one entity (such as a treatment, drug, or procedure) should not be used or performed in the presence of another entity (such as a condition, factor, or co-medication) because it may cause harm or adverse effects.
Aliases (5)
- contraindicatedIn ×14
- contraindication ×8
- isContraindicatedIn ×3
- drugInteractionWarning ×2
- isContraindicatedWith ×2
Sample triples (36)
| Subject | Object |
|---|---|
| Activase | active internal bleeding ("contraindicatedIn") → |
| Activase | history of recent intracranial hemorrhage ("contraindicatedIn") → |
| Activase | suspected subarachnoid hemorrhage ("contraindicatedIn") → |
| Avastin | recent major surgery ("contraindication") → |
| Avastin | uncontrolled hypertension ("contraindication") → |
| Darzalex | severe hypersensitivity to daratumumab ("contraindication") → |
| Fampyra | history of seizures ("contraindicatedIn") → |
| Fampyra | moderate or severe renal impairment ("contraindicatedIn") → |
| Herceptin | severe hypersensitivity to trastuzumab ("isContraindicatedWith") → |
| Imbruvica | strong CYP3A4 inhibitors ("isContraindicatedWith") → |
| Janssen COVID-19 Vaccine | known severe allergy to a component of the vaccine ("contraindication") → |
| Janssen COVID-19 Vaccine | severe allergic reaction to a previous dose ("contraindication") → |
| Lucentis | known hypersensitivity to ranibizumab ("contraindicatedIn") → |
| Lucentis | ocular or periocular infection ("contraindicatedIn") → |
| Perjeta | pregnancy ("contraindication") → |
| Plegridy | history of suicidal ideation → |
| Plegridy | severe depression → |
| Plegridy | severe hepatic impairment → |
| Remicade | patients with active serious infections ("isContraindicatedIn") → |
| Remicade | severe heart failure ("isContraindicatedIn") → |
| Rituxan | known severe hypersensitivity to rituximab ("contraindicatedIn") → |
| Stelara | patients with clinically significant hypersensitivity to ustekinumab ("isContraindicatedIn") → |
| Tecfidera | known hypersensitivity to dimethyl fumarate → |
| Tylenol | alcohol increases risk of liver toxicity ("drugInteractionWarning") → |
| Tylenol | other acetaminophen-containing products increase overdose risk ("drugInteractionWarning") → |
| Tysabri | patients with a history of progressive multifocal leukoencephalopathy ("contraindicatedIn") → |
| Tysabri | patients with severely compromised immune systems ("contraindicatedIn") → |
| Vumerity | known hypersensitivity to dimethyl fumarate ("contraindicatedIn") → |
| Vumerity | known hypersensitivity to diroximel fumarate ("contraindicatedIn") → |
| Xarelto | active pathological bleeding → |
| Xarelto | severe hypersensitivity to rivaroxaban → |
| Xarelto | significant hepatic disease associated with coagulopathy → |
| oseltamivir | patients with known hypersensitivity to oseltamivir ("contraindicatedIn") → |
| rVSV-ZEBOV | use in certain immunocompromised individuals may be restricted ("contraindication") → |
| rVSV-ZEBOV | use in pregnancy may be restricted ("contraindication") → |
| zanamivir | patients with severe milk protein allergy ("contraindicatedIn") → |