Tecfidera
E25438
Tecfidera is an oral disease-modifying medication used to treat relapsing forms of multiple sclerosis by reducing inflammation and relapse frequency.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
disease-modifying therapy
→
multiple sclerosis medication → pharmaceutical drug → |
| belongsToClass |
fumaric acid esters
→
immunosuppressive agents → |
| hasActiveIngredient | dimethyl fumarate → |
| hasAdministrationFrequency | twice daily → |
| hasApprovalBy |
European Medicines Agency
→
Food and Drug Administration →
surface form: "U.S. Food and Drug Administration"
|
| hasATCCode | L04AX07 → |
| hasChemicalFormula | C6H8O4 → |
| hasCommonSideEffect |
abdominal pain
→
diarrhea → flushing → nausea → pruritus → rash → vomiting → |
| hasContraindication | known hypersensitivity to dimethyl fumarate → |
| hasDosageForm | delayed-release capsule → |
| hasEffectOn | absolute lymphocyte count → |
| hasFDAApprovalYear | 2013 → |
| hasGenericName | dimethyl fumarate → |
| hasInitialDose | 120 mg twice daily → |
| hasLegalStatus | prescription-only → |
| hasMaintenanceDose | 240 mg twice daily → |
| hasMechanismOfAction |
anti-inflammatory
→
immunomodulatory → |
| hasMolecularWeight | 144.13 g/mol → |
| hasPregnancyCategory | use only if potential benefit justifies potential risk → |
| hasRouteOfAdministration | oral → |
| hasSeriousAdverseEffect |
liver injury
→
lymphopenia → progressive multifocal leukoencephalopathy → |
| isManufacturedBy | Biogen → |
| isProdrugOf | monomethyl fumarate → |
| isTakenWith | food → |
| mayCause | flushing mediated by prostaglandins → |
| reduces |
magnetic resonance imaging lesion activity in multiple sclerosis
→
relapse frequency in multiple sclerosis → risk of disability progression in multiple sclerosis → |
| requiresMonitoring |
liver function tests
→
lymphocyte count → |
| targetsPathway | Nrf2 pathway → |
| treats |
active secondary progressive multiple sclerosis
→
clinically isolated syndrome → relapsing forms of multiple sclerosis → relapsing-remitting multiple sclerosis → |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.