Activase
E46090
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
Aliases (1)
- alteplase ×3
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
brand-name drug
→
fibrinolytic drug → prescription medicine → thrombolytic agent → |
| affectsBiologicalProcess |
fibrinolysis
→
|
| contraindicatedIn |
active internal bleeding
→
history of recent intracranial hemorrhage → suspected subarachnoid hemorrhage → |
| developedBy |
Genentech
→
|
| hasActiveIngredient |
alteplase
→
|
| hasATCCode |
B01AD02
→
|
| hasDosageForm |
lyophilized powder for solution
→
|
| hasDrugClass |
fibrinolytic
→
thrombolytic → tissue plasminogen activator → |
| hasGenericName |
alteplase
→
|
| hasManufacturer |
Genentech
→
|
| hasPregnancyCategory |
use only if potential benefit justifies potential risk
→
|
| hasRegulatoryStatus |
prescription only
→
|
| hasTarget |
plasminogen
→
|
| indicatedFor |
ST-elevation myocardial infarction
→
acute ischemic stroke → acute massive pulmonary embolism → acute myocardial infarction → pulmonary embolism → restoration of function to occluded central venous access devices → |
| isAdministeredBy |
healthcare professional
→
|
| isApprovedBy |
U.S. Food and Drug Administration
→
|
| isBrandOf |
alteplase
→
|
| isGivenAs |
intravenous bolus followed by infusion (indication-specific)
→
|
| isMarketedIn |
United States
→
|
| isReconstitutedWith |
sterile water for injection
→
|
| isUsedAs |
clot-dissolving drug
→
thrombolytic treatment → |
| majorAdverseEffect |
intracranial hemorrhage
→
major bleeding → orolingual angioedema → |
| mechanismOfAction |
converts plasminogen to plasmin
→
promotes fibrin clot breakdown → |
| requiresImagingBeforeUse |
brain imaging to exclude hemorrhage
→
|
| requiresMonitoringOf |
blood pressure
→
neurological status → signs of bleeding → |
| routeOfAdministration |
intravenous
→
|
| timeWindowForAcuteIschemicStroke |
within several hours of symptom onset
→
|
| treatsPathophysiologicProcess |
thrombus formation
→
|
| usedWithinTimeWindowFor |
acute ischemic stroke
→
|
Referenced by (4)
| Subject (surface form when different) | Predicate |
|---|---|
|
Activase
("alteplase")
→
|
hasActiveIngredient |
|
Activase
("alteplase")
→
|
hasGenericName |
|
Activase
("alteplase")
→
|
isBrandOf |
|
Genentech
→
|
notableProduct |