non-Hodgkin lymphoma
E99398
Non-Hodgkin lymphoma is a diverse group of blood cancers that originate in the lymphatic system from abnormal lymphocytes and can vary widely in aggressiveness and prognosis.
Aliases (6)
Statements (84)
| Predicate | Object |
|---|---|
| instanceOf |
blood cancer
→
group of hematologic malignancies → lymphoid neoplasm → lymphoma → |
| hasCellTypeOfOrigin |
B cell
→
NK cell → T cell → lymphocyte → |
| hasClassification |
aggressive lymphoma
→
highly aggressive lymphoma → indolent lymphoma → |
| hasCommonDrug |
cyclophosphamide
→
doxorubicin → prednisone → rituximab → vincristine → |
| hasCommonTreatment |
CAR T-cell therapy
→
chemotherapy → immunotherapy → radiation therapy → stem cell transplantation → targeted therapy → |
| hasEpidemiology |
incidence increases with age
→
more common in adults than in children → one of the most common cancers worldwide → slightly more common in males → |
| hasInfectiousAssociation |
Epstein–Barr virus infection
→
HHV-8 infection → HTLV-1 infection → Helicobacter pylori infection → hepatitis C virus infection → |
| hasOrigin |
lymphatic system
→
|
| hasPossibleSymptom |
abdominal pain or fullness
→
chest pain or cough → fatigue → fever → night sweats → pruritus → unintentional weight loss → |
| hasPrognosticFactor |
age
→
disease stage → performance status → serum LDH level → |
| hasPrognosticIndex |
International Prognostic Index
→
|
| hasProperty |
heterogeneous group of diseases
→
variable aggressiveness → variable prognosis → |
| hasRiskFactor |
HIV infection
→
advanced age → autoimmune disease → exposure to benzene → exposure to certain pesticides → family history of lymphoma → immunodeficiency → organ transplantation → prior chemotherapy → prior radiation therapy → |
| hasSubtype |
Burkitt lymphoma
→
NK/T-cell lymphoma, nasal type → Waldenström macroglobulinemia → anaplastic large cell lymphoma → cutaneous T-cell lymphoma → diffuse large B-cell lymphoma → follicular lymphoma → lymphoblastic lymphoma → mantle cell lymphoma → marginal zone lymphoma → peripheral T-cell lymphoma → primary CNS lymphoma → primary mediastinal large B-cell lymphoma → small lymphocytic lymphoma → |
| hasTypicalSymptom |
painless lymphadenopathy
→
|
| isCharacterizedBy |
abnormal proliferation of lymphocytes
→
clonal lymphoid cells → |
| isDiagnosedBy |
cytogenetic analysis
→
flow cytometry → histopathologic examination → immunophenotyping → lymph node biopsy → molecular testing → |
| isDifferentFrom |
Hodgkin lymphoma
→
|
| isStagedBy |
Ann Arbor staging system
→
Lugano classification → |
| partOf |
hematologic malignancies
→
|
Referenced by (9)
| Subject (surface form when different) | Predicate |
|---|---|
|
non-Hodgkin lymphoma
("follicular lymphoma")
→
non-Hodgkin lymphoma ("Burkitt lymphoma") → non-Hodgkin lymphoma ("peripheral T-cell lymphoma") → non-Hodgkin lymphoma ("NK/T-cell lymphoma, nasal type") → non-Hodgkin lymphoma ("Waldenström macroglobulinemia") → |
hasSubtype |
|
Jacqueline Kennedy Onassis
→
Paul Allen → |
causeOfDeath |
|
non-Hodgkin lymphoma
("Epstein–Barr virus infection")
→
|
hasInfectiousAssociation |
|
Rituxan
→
|
indicatedFor |