CD38
E241387
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
All labels observed (2)
How this entity was disambiguated
This entity first appeared as the object of triple T2190704 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CD38 Context triple: [Darzalex, targets, CD38]
-
A.
Lextran
Lextran is the public bus transit system serving Lexington and surrounding areas in Fayette County, Kentucky.
-
B.
C-3a
C-3a is a commuter rail line within the Cercanías Madrid network serving suburban areas around Spain’s capital.
-
C.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
D.
CASP13
CASP13 is the 13th Critical Assessment of protein Structure Prediction experiment, an international community-wide competition that benchmarks computational methods for predicting 3D protein structures.
-
E.
FACS
FACS is a professional designation indicating a surgeon is a Fellow of the American College of Surgeons and meets its standards of education, training, and ethical practice.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CD38 Target entity description: CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
A.
Lextran
Lextran is the public bus transit system serving Lexington and surrounding areas in Fayette County, Kentucky.
-
B.
C-3a
C-3a is a commuter rail line within the Cercanías Madrid network serving suburban areas around Spain’s capital.
-
C.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
D.
CASP13
CASP13 is the 13th Critical Assessment of protein Structure Prediction experiment, an international community-wide competition that benchmarks computational methods for predicting 3D protein structures.
-
E.
FACS
FACS is a professional designation indicating a surgeon is a Fellow of the American College of Surgeons and meets its standards of education, training, and ethical practice.
- F. None of above. chosen
Statements (59)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface glycoprotein
ⓘ
cluster of differentiation antigen ⓘ ectoenzyme ⓘ human protein ⓘ receptor ⓘ |
| associatedWith |
aging-related NAD decline
ⓘ
immune cell exhaustion ⓘ inflammation ⓘ |
| belongsToFamily | ADP-ribosyl cyclase family ⓘ |
| encodedBy |
CD38
self-linksurface differs
ⓘ
surface form:
CD38 gene
|
| expressedOn |
activated B cells
ⓘ
activated T cells ⓘ hematopoietic progenitor cells ⓘ monocytes ⓘ myeloid cells ⓘ natural killer cells ⓘ plasma cells ⓘ some non-hematopoietic tissues ⓘ |
| foundInSpecies |
Homo sapiens
ⓘ
house mouse (Mus musculus) ⓘ
surface form:
Mus musculus
|
| hasBiologicalProcess |
calcium signaling regulation
ⓘ
cell adhesion ⓘ immune response regulation ⓘ signal transduction ⓘ |
| hasDomain |
extracellular catalytic domain
ⓘ
short cytoplasmic tail ⓘ |
| hasMolecularFunction |
ADP-ribosyl cyclase activity
ⓘ
NAD glycohydrolase activity ⓘ cyclic ADP-ribose hydrolase activity ⓘ |
| hasPostTranslationalModification | N-linked glycosylation ⓘ |
| hasRole |
cell activation
ⓘ
cell proliferation ⓘ cell survival ⓘ generation of cyclic ADP-ribose ⓘ modulation of intracellular calcium release ⓘ regulation of NAD metabolism ⓘ |
| highlyExpressedIn |
multiple myeloma cells
ⓘ
plasma cell leukemia cells ⓘ some acute myeloid leukemia cells ⓘ some chronic lymphocytic leukemia cells ⓘ |
| locatedIn | cell membrane ⓘ |
| subcellularLocation | type II transmembrane protein ⓘ |
| targetOf |
CD38-directed CAR T-cell therapies
ⓘ
CD38-directed antibody-drug conjugates ⓘ CD38-directed bispecific antibodies ⓘ MOR202 ⓘ TAK-079 ⓘ daratumumab ⓘ isatuximab ⓘ |
| therapeuticArea |
non-Hodgkin lymphoma
ⓘ
surface form:
NK/T-cell lymphoma
T-cell acute lymphoblastic leukemia ⓘ acute myeloid leukemia ⓘ autoimmune diseases ⓘ chronic lymphocytic leukemia ⓘ light chain amyloidosis ⓘ multiple myeloma ⓘ |
| usedAs |
diagnostic marker for plasma cells
ⓘ
marker for hematopoietic cell subsets ⓘ prognostic marker in chronic lymphocytic leukemia ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CD38 Description of subject: CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.