BTK

E561038

Bruton’s tyrosine kinase protein

BTK (Bruton’s tyrosine kinase) is a key signaling enzyme in B cells and a major therapeutic target in certain blood cancers and autoimmune diseases.

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Observed surface forms (1)

Surface form	Occurrences
BTK tyrosine kinase	1

Statements (56)

Predicate	Object
instanceOf	Bruton’s tyrosine kinase ⓘ protein ⓘ
activatedBy	SYK ⓘ Src family kinases NERFINISHED ⓘ phosphorylation at Y551 ⓘ
associatedWithDisease	Waldenström macroglobulinemia NERFINISHED ⓘ X-linked agammaglobulinemia ⓘ autoimmune diseases ⓘ chronic lymphocytic leukemia NERFINISHED ⓘ diffuse large B-cell lymphoma ⓘ mantle cell lymphoma NERFINISHED ⓘ
belongsToFamily	Tec family kinases NERFINISHED ⓘ
binds	BLNK ⓘ PLCγ2 NERFINISHED ⓘ phosphatidylinositol 3,4,5-trisphosphate ⓘ
chromosomalLocation	Xq21.3–Xq22 ⓘ
discoveredBy	Ogden Bruton NERFINISHED ⓘ
encodedBy	BTK gene ⓘ
expressedIn	B lymphocytes NERFINISHED ⓘ mast cells ⓘ myeloid cells ⓘ platelets ⓘ
hasDomain	Pleckstrin homology domain ⓘ SH2 domain ⓘ SH3 domain NERFINISHED ⓘ Tec homology domain ⓘ tyrosine kinase domain ⓘ
hasMolecularFunction	ATP binding ⓘ protein phosphorylation ⓘ protein tyrosine kinase activity ⓘ
hasMutationConsequence	loss-of-function mutations cause X-linked agammaglobulinemia ⓘ
inhibitedBy	acalabrutinib NERFINISHED ⓘ ibrutinib NERFINISHED ⓘ pirtobrutinib NERFINISHED ⓘ spebrutinib NERFINISHED ⓘ tirabrutinib NERFINISHED ⓘ zanubrutinib NERFINISHED ⓘ
isTherapeuticTargetIn	B cell malignancies ⓘ Waldenström macroglobulinemia NERFINISHED ⓘ autoimmune diseases ⓘ chronic lymphocytic leukemia ⓘ mantle cell lymphoma ⓘ
locatedIn	cytoplasm ⓘ plasma membrane ⓘ
namedAfter	Ogden Bruton NERFINISHED ⓘ
partOf	B cell activation pathway ⓘ B cell receptor signaling pathway ⓘ
playsRoleIn	B cell development ⓘ B cell differentiation ⓘ B cell maturation ⓘ B cell proliferation ⓘ B cell survival ⓘ MAPK pathway activation ⓘ NF-κB activation ⓘ calcium signaling in B cells ⓘ signal transduction ⓘ

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

Loxo Oncology (acquired) → drugTarget → BTK ⓘ

subject surface form: Loxo Oncology

Bruton tyrosine kinase → hasAbbreviation → BTK ⓘ

Bruton tyrosine kinase → hasAlternativeName → BTK ⓘ

this entity surface form: BTK tyrosine kinase