Toll-like receptor signaling pathway
E888595
The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
biological pathway
ⓘ
innate immune signaling pathway ⓘ signal transduction pathway ⓘ |
| activatedBy |
bacterial lipopolysaccharide
ⓘ
bacterial lipoprotein ⓘ flagellin ⓘ viral DNA ⓘ viral RNA ⓘ |
| associatedWith |
autoimmune disease
ⓘ
chronic inflammation ⓘ infectious disease ⓘ |
| detects |
DAMP
ⓘ
PAMP ⓘ damage-associated molecular pattern ⓘ pathogen-associated molecular pattern ⓘ |
| foundIn |
human
ⓘ
mammal ⓘ mouse ⓘ |
| hasParticipant |
AP-1 transcription factor
ⓘ
ERK NERFINISHED ⓘ IKK complex NERFINISHED ⓘ IRAK1 NERFINISHED ⓘ IRAK4 NERFINISHED ⓘ IRF3 NERFINISHED ⓘ IRF7 NERFINISHED ⓘ JNK NERFINISHED ⓘ MAPK cascade ⓘ MyD88 NERFINISHED ⓘ NF-κB NERFINISHED ⓘ TAK1 NERFINISHED ⓘ TIRAP NERFINISHED ⓘ TLR1 NERFINISHED ⓘ TLR10 NERFINISHED ⓘ TLR2 NERFINISHED ⓘ TLR3 NERFINISHED ⓘ TLR4 NERFINISHED ⓘ TLR5 NERFINISHED ⓘ TLR6 NERFINISHED ⓘ TLR7 NERFINISHED ⓘ TLR8 NERFINISHED ⓘ TLR9 NERFINISHED ⓘ TRAF6 NERFINISHED ⓘ TRAM ⓘ TRIF NERFINISHED ⓘ Toll-like receptor NERFINISHED ⓘ p38 MAPK NERFINISHED ⓘ |
| hasSubPathway |
MyD88-dependent TLR signaling pathway
ⓘ
TRIF-dependent TLR signaling pathway ⓘ |
| occursIn |
dendritic cell
ⓘ
epithelial cell ⓘ macrophage ⓘ neutrophil NERFINISHED ⓘ |
| partOf |
immune system
ⓘ
innate immune system ⓘ |
| regulates |
adaptive immune response
ⓘ
co-stimulatory molecule expression ⓘ cytokine gene expression ⓘ |
| resultsIn |
antiviral response
ⓘ
chemokine production ⓘ inflammatory response ⓘ pro-inflammatory cytokine production ⓘ type I interferon production ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.