Gi protein

E275980

G protein alpha subunit family heterotrimeric G protein

Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.

Try in SPARQL Jump to: Surface forms Statements Referenced by

All labels observed (2)

Label	Occurrences
GNAI1 gene (for Gαi1 in humans)	1
Gi protein canonical	1

Statements (49)

Predicate	Object
instanceOf	G protein alpha subunit family ⓘ heterotrimeric G protein ⓘ
activatedBy	G protein–coupled receptors ⓘ
activatedForm	GTP-bound Gαi ⓘ
belongsToPathway	inhibitory G protein signaling pathway ⓘ
bindsNucleotide	GDP ⓘ GTP ⓘ
canBeInhibitedBy	pertussis toxin ⓘ
couplesToReceptor	Gi-coupled GPCR ⓘ M2 muscarinic acetylcholine receptor ⓘ dopamine D2 receptor ⓘ somatostatin receptor ⓘ α2-adrenergic receptor ⓘ μ-opioid receptor ⓘ
downstreamEffect	altered gene transcription via CREB ⓘ reduced protein kinase A activity ⓘ
encodedBy	Gi protein self-linksurface differs ⓘ surface form: GNAI1 gene (for Gαi1 in humans) GNAI2 gene (for Gαi2 in humans) ⓘ GNAI3 gene (for Gαi3 in humans) ⓘ
foundIn	humans ⓘ mammals ⓘ rodents ⓘ
GβγSubunits	regulate ion channels ⓘ regulate phospholipase C β ⓘ
hasActivity	GTPase activity ⓘ
hasOrtholog	Gαi proteins in multiple vertebrate species ⓘ
hasSubunit	Gαi ⓘ Gβ ⓘ Gγ ⓘ
inactiveForm	GDP-bound Gαiβγ trimer ⓘ
inhibits	adenylyl cyclase ⓘ
involvedIn	cardiac function regulation ⓘ pain signaling pathways ⓘ regulation of hormone secretion ⓘ regulation of neurotransmitter release ⓘ smooth muscle contraction ⓘ vision-related signaling in some cells ⓘ
locatedIn	plasma membrane ⓘ
modulates	intracellular signaling pathways ⓘ ion channel activity ⓘ
molecularFunction	GTP binding ⓘ signal transducer activity ⓘ
negativelyRegulates	cAMP levels ⓘ
participatesIn	G protein–coupled receptor signaling pathway ⓘ
pertussisToxinEffect	ADP-ribosylation of Gαi ⓘ prevention of receptor–G protein coupling ⓘ
regulates	cyclic AMP biosynthetic process ⓘ
taxon	Eukarya ⓘ surface form: Eukaryota
uponActivation	dissociation of Gαi from Gβγ ⓘ

Referenced by (2)

Full triples — surface form annotated when it differs from this entity's canonical label.

CB1 receptor → coupledTo → Gi protein ⓘ

Gi protein → encodedBy → Gi protein self-linksurface differs ⓘ

this entity surface form: GNAI1 gene (for Gαi1 in humans)