M2 muscarinic acetylcholine receptor
E874316
G protein–coupled receptor
integral membrane protein
membrane protein
muscarinic acetylcholine receptor subtype
seven-transmembrane receptor
The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
G protein–coupled receptor
ⓘ
integral membrane protein ⓘ membrane protein ⓘ muscarinic acetylcholine receptor subtype ⓘ seven-transmembrane receptor ⓘ |
| activatedBy |
parasympathetic nervous system
NERFINISHED
ⓘ
vagal stimulation ⓘ |
| agonist |
carbachol
ⓘ
oxotremorine ⓘ |
| antagonist |
AF-DX 116
ⓘ
atropine ⓘ gallamine ⓘ methoctramine ⓘ scopolamine ⓘ |
| belongsToFamily |
class A GPCR
ⓘ
muscarinic receptor family NERFINISHED ⓘ |
| cellularComponent | plasma membrane ⓘ |
| clinicalRelevance |
involved in vagally mediated bradycardia
ⓘ
target in treatment of cardiac arrhythmias ⓘ |
| contrastsWith |
M1 muscarinic acetylcholine receptor
NERFINISHED
ⓘ
M3 muscarinic acetylcholine receptor NERFINISHED ⓘ |
| couplesTo |
Gi protein
ⓘ
Go protein ⓘ |
| downstreamEffect |
hyperpolarizes cardiac pacemaker cells
ⓘ
opens G protein–gated inwardly rectifying K+ channels ⓘ |
| effectOnSecondMessenger | decreases cAMP levels ⓘ |
| encodedBy | CHRM2 gene NERFINISHED ⓘ |
| foundIn |
central nervous system
ⓘ
presynaptic nerve terminals ⓘ smooth muscle ⓘ |
| hasTransmembraneDomains | 7 ⓘ |
| ligand |
acetylcholine
ⓘ
muscarine ⓘ |
| organism | human ⓘ |
| pharmacologicalProfile | prefers Gi/Go coupling over Gq/11 ⓘ |
| physiologicalRole |
inhibits neurotransmitter release at some synapses
ⓘ
mediates parasympathetic effects in the heart ⓘ reduces cardiac contractility ⓘ slows atrioventricular conduction ⓘ slows heart rate ⓘ |
| primaryLocation |
atria
ⓘ
atrioventricular node ⓘ cardiac conduction system ⓘ heart ⓘ sinoatrial node NERFINISHED ⓘ |
| receptorSubtype | M2 NERFINISHED ⓘ |
| signalPathway | inhibition of adenylyl cyclase ⓘ |
| speciesContext | Homo sapiens ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.