GNAI2 gene (for Gαi2 in humans)
E876001
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
All labels observed (1)
| Label | Occurrences |
|---|---|
| GNAI2 gene (for Gαi2 in humans) canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10610034 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: GNAI2 gene (for Gαi2 in humans) Context triple: [Gi protein, encodedBy, GNAI2 gene (for Gαi2 in humans)]
-
A.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
B.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
C.
ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
D.
Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
-
E.
HTT gene
The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: GNAI2 gene (for Gαi2 in humans) Target entity description: The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
-
A.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
B.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
C.
ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
D.
Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
-
E.
HTT gene
The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf | protein-coding gene ⓘ |
| activatedBy |
G protein–coupled receptors
NERFINISHED
ⓘ
guanine nucleotide exchange from GDP to GTP ⓘ |
| alias |
G protein alpha inhibiting activity polypeptide 2
NERFINISHED
ⓘ
GNAI2 gene NERFINISHED ⓘ Gαi2 gene NERFINISHED ⓘ |
| associatedWith |
cardiovascular signaling pathways
ⓘ
immune cell signaling ⓘ neural signaling pathways ⓘ pertussis toxin–sensitive G protein signaling ⓘ |
| biologicalProcess |
G protein–coupled receptor signaling pathway, coupled to inhibition of adenylate cyclase
ⓘ
inhibition of adenylate cyclase activity ⓘ regulation of cAMP biosynthetic process ⓘ regulation of hormone-mediated signaling pathway ⓘ regulation of neurotransmitter signaling ⓘ signal transduction ⓘ |
| cellularComponent |
cytoplasm
ⓘ
heterotrimeric G protein complex ⓘ plasma membrane ⓘ |
| encodes |
G alpha i2 protein
NERFINISHED
ⓘ
G protein subunit alpha i2 NERFINISHED ⓘ Gαi2 alpha subunit ⓘ |
| expressedIn |
brain
ⓘ
heart ⓘ immune cells ⓘ |
| geneType | protein coding ⓘ |
| hasDomain | GTP-binding P-loop NTPase domain ⓘ |
| hasOrtholog |
Gnai2 (mouse)
NERFINISHED
ⓘ
Gnai2 (rat) ⓘ |
| inactivatedBy |
intrinsic GTPase activity
ⓘ
regulators of G protein signaling proteins ⓘ |
| locatedOnChromosome | human chromosome 3 ⓘ |
| molecularFunction |
GDP binding
ⓘ
GTP binding ⓘ GTPase activity ⓘ adenylyl cyclase inhibitor activity ⓘ |
| organism | Homo sapiens ⓘ |
| participatesIn |
G protein–coupled receptor signaling pathway
ⓘ
heterotrimeric G protein signaling pathway ⓘ |
| postTranslationalModification |
myristoylation of Gαi2 protein
ⓘ
palmitoylation of Gαi2 protein ⓘ |
| regulates |
adenylyl cyclase
ⓘ
cAMP levels ⓘ hormone receptor signaling ⓘ ion channel activity ⓘ neurotransmitter receptor signaling ⓘ |
| subunitOf |
G alpha i/o family
NERFINISHED
ⓘ
Gi heterotrimeric G protein NERFINISHED ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: GNAI2 gene (for Gαi2 in humans) Description of subject: The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.