GNAI2 gene (for Gαi2 in humans)
E876001
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| GNAI2 | 0 |
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf | protein-coding gene ⓘ |
| activatedBy |
G protein–coupled receptors
NERFINISHED
ⓘ
guanine nucleotide exchange from GDP to GTP ⓘ |
| alias |
G protein alpha inhibiting activity polypeptide 2
NERFINISHED
ⓘ
GNAI2 gene NERFINISHED ⓘ Gαi2 gene NERFINISHED ⓘ |
| associatedWith |
cardiovascular signaling pathways
ⓘ
immune cell signaling ⓘ neural signaling pathways ⓘ pertussis toxin–sensitive G protein signaling ⓘ |
| biologicalProcess |
G protein–coupled receptor signaling pathway, coupled to inhibition of adenylate cyclase
ⓘ
inhibition of adenylate cyclase activity ⓘ regulation of cAMP biosynthetic process ⓘ regulation of hormone-mediated signaling pathway ⓘ regulation of neurotransmitter signaling ⓘ signal transduction ⓘ |
| cellularComponent |
cytoplasm
ⓘ
heterotrimeric G protein complex ⓘ plasma membrane ⓘ |
| encodes |
G alpha i2 protein
NERFINISHED
ⓘ
G protein subunit alpha i2 NERFINISHED ⓘ Gαi2 alpha subunit ⓘ |
| expressedIn |
brain
ⓘ
heart ⓘ immune cells ⓘ |
| geneType | protein coding ⓘ |
| hasDomain | GTP-binding P-loop NTPase domain ⓘ |
| hasOrtholog |
Gnai2 (mouse)
NERFINISHED
ⓘ
Gnai2 (rat) ⓘ |
| inactivatedBy |
intrinsic GTPase activity
ⓘ
regulators of G protein signaling proteins ⓘ |
| locatedOnChromosome | human chromosome 3 ⓘ |
| molecularFunction |
GDP binding
ⓘ
GTP binding ⓘ GTPase activity ⓘ adenylyl cyclase inhibitor activity ⓘ |
| organism | Homo sapiens ⓘ |
| participatesIn |
G protein–coupled receptor signaling pathway
ⓘ
heterotrimeric G protein signaling pathway ⓘ |
| postTranslationalModification |
myristoylation of Gαi2 protein
ⓘ
palmitoylation of Gαi2 protein ⓘ |
| regulates |
adenylyl cyclase
ⓘ
cAMP levels ⓘ hormone receptor signaling ⓘ ion channel activity ⓘ neurotransmitter receptor signaling ⓘ |
| subunitOf |
G alpha i/o family
NERFINISHED
ⓘ
Gi heterotrimeric G protein NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.