Triple

T10610034
Position Surface form Disambiguated ID Type / Status
Subject Gi protein E275980 entity
Predicate encodedBy P14248 FINISHED
Object GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
E876001 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: GNAI2 gene (for Gαi2 in humans) | Statement: [Gi protein, encodedBy, GNAI2 gene (for Gαi2 in humans)]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: GNAI2 gene (for Gαi2 in humans)
Context triple: [Gi protein, encodedBy, GNAI2 gene (for Gαi2 in humans)]
  • A. Gi protein
    Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
  • B. GNAS
    GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
  • C. ABCG2 gene
    The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
  • D. Gi-coupled GPCR
    A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
  • E. HTT gene
    The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: GNAI2 gene (for Gαi2 in humans)
Triple: [Gi protein, encodedBy, GNAI2 gene (for Gαi2 in humans)]
Generated description
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: GNAI2 gene (for Gαi2 in humans)
Target entity description: The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
  • A. Gi protein
    Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
  • B. GNAS
    GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
  • C. ABCG2 gene
    The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
  • D. Gi-coupled GPCR
    A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
  • E. HTT gene
    The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d6aaf948d88190806cc3a8c47a3fb2 completed April 8, 2026, 7:22 p.m.
NER Named-entity recognition batch_69d6df59468881909b0c67d3f08c4b76 completed April 8, 2026, 11:06 p.m.
NED1 Entity disambiguation (via context triple) batch_69d96b716a088190b84982f1a8173e0a completed April 10, 2026, 9:28 p.m.
NEDg Description generation batch_69d96dee84f48190bf5b0cb1115a8bba completed April 10, 2026, 9:38 p.m.
NED2 Entity disambiguation (via description) batch_69d9708824208190acf75933962d690f completed April 10, 2026, 9:50 p.m.
Created at: April 8, 2026, 7:32 p.m.