GNAI3 gene (for Gαi3 in humans)
E876997
The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| GNAI3 | 0 |
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf | protein-coding gene ⓘ |
| associatedWith |
auriculocondylar syndrome
NERFINISHED
ⓘ
craniofacial developmental disorders ⓘ |
| belongsToFamily | G alpha i/o family NERFINISHED ⓘ |
| belongsToPathway |
Gi-coupled GPCR signaling pathway
ⓘ
inhibition of adenylate cyclase pathway ⓘ |
| encodes |
G protein subunit alpha i3
NERFINISHED
ⓘ
Gαi3 NERFINISHED ⓘ |
| expressedIn |
human brain
ⓘ
human heart ⓘ human immune cells ⓘ human kidney ⓘ |
| hasAlias |
GNAI-3
NERFINISHED
ⓘ
Gi alpha-3 ⓘ Gαi3 ⓘ |
| hasGeneID | NCBI Gene:2773 ⓘ |
| hasGeneProduct | UniProt:P08754 ⓘ |
| hasHGNCID | HGNC:4395 ⓘ |
| hasMolecularFunction |
GTP binding
ⓘ
GTPase activity ⓘ signal transducer activity ⓘ |
| hasOrtholog |
mouse Gnai3
ⓘ
rat Gnai3 ⓘ |
| inhibits | adenylate cyclase ⓘ |
| interactsWith |
GNB1
ⓘ
GNG2 NERFINISHED ⓘ RGS proteins NERFINISHED ⓘ adenylate cyclase isoforms ⓘ |
| involvedIn |
GTP-dependent protein signaling
ⓘ
chemokine receptor signaling pathway ⓘ regulation of intracellular cAMP levels ⓘ signal transduction ⓘ |
| locatedIn | Homo sapiens NERFINISHED ⓘ |
| locatedOnChromosome | human chromosome 1 ⓘ |
| negativelyRegulates | cAMP biosynthetic process ⓘ |
| participatesIn |
G protein–coupled receptor signaling pathway
ⓘ
heterotrimeric G protein signaling pathway ⓘ inhibitory G protein–coupled receptor signaling ⓘ |
| positivelyRegulates | MAPK cascade via GPCR signaling ⓘ |
| productInstanceOf |
G protein alpha subunit
ⓘ
Gi alpha subunit ⓘ heterotrimeric G protein alpha subunit ⓘ |
| regulatedBy | G protein–coupled receptors NERFINISHED ⓘ |
| regulates |
adenylate cyclase activity
ⓘ
cyclic AMP signaling ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
inner leaflet of plasma membrane ⓘ plasma membrane ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.