GNAI3 gene (for Gαi3 in humans)
E876997
The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.
All labels observed (1)
| Label | Occurrences |
|---|---|
| GNAI3 gene (for Gαi3 in humans) canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10610035 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: GNAI3 gene (for Gαi3 in humans) Context triple: [Gi protein, encodedBy, GNAI3 gene (for Gαi3 in humans)]
-
A.
GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
-
B.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
C.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
D.
ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
E.
Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: GNAI3 gene (for Gαi3 in humans) Target entity description: The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.
-
A.
GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
-
B.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
C.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
D.
ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
E.
Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf | protein-coding gene ⓘ |
| associatedWith |
auriculocondylar syndrome
NERFINISHED
ⓘ
craniofacial developmental disorders ⓘ |
| belongsToFamily | G alpha i/o family NERFINISHED ⓘ |
| belongsToPathway |
Gi-coupled GPCR signaling pathway
ⓘ
inhibition of adenylate cyclase pathway ⓘ |
| encodes |
G protein subunit alpha i3
NERFINISHED
ⓘ
Gαi3 NERFINISHED ⓘ |
| expressedIn |
human brain
ⓘ
human heart ⓘ human immune cells ⓘ human kidney ⓘ |
| hasAlias |
GNAI-3
NERFINISHED
ⓘ
Gi alpha-3 ⓘ Gαi3 ⓘ |
| hasGeneID | NCBI Gene:2773 ⓘ |
| hasGeneProduct | UniProt:P08754 ⓘ |
| hasHGNCID | HGNC:4395 ⓘ |
| hasMolecularFunction |
GTP binding
ⓘ
GTPase activity ⓘ signal transducer activity ⓘ |
| hasOrtholog |
mouse Gnai3
ⓘ
rat Gnai3 ⓘ |
| inhibits | adenylate cyclase ⓘ |
| interactsWith |
GNB1
ⓘ
GNG2 NERFINISHED ⓘ RGS proteins NERFINISHED ⓘ adenylate cyclase isoforms ⓘ |
| involvedIn |
GTP-dependent protein signaling
ⓘ
chemokine receptor signaling pathway ⓘ regulation of intracellular cAMP levels ⓘ signal transduction ⓘ |
| locatedIn | Homo sapiens NERFINISHED ⓘ |
| locatedOnChromosome | human chromosome 1 ⓘ |
| negativelyRegulates | cAMP biosynthetic process ⓘ |
| participatesIn |
G protein–coupled receptor signaling pathway
ⓘ
heterotrimeric G protein signaling pathway ⓘ inhibitory G protein–coupled receptor signaling ⓘ |
| positivelyRegulates | MAPK cascade via GPCR signaling ⓘ |
| productInstanceOf |
G protein alpha subunit
ⓘ
Gi alpha subunit ⓘ heterotrimeric G protein alpha subunit ⓘ |
| regulatedBy | G protein–coupled receptors NERFINISHED ⓘ |
| regulates |
adenylate cyclase activity
ⓘ
cyclic AMP signaling ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
inner leaflet of plasma membrane ⓘ plasma membrane ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: GNAI3 gene (for Gαi3 in humans) Description of subject: The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.