adenylyl cyclase
E874313
Adenylyl cyclase is a membrane-bound enzyme that converts ATP to the second messenger cyclic AMP, playing a central role in many signal transduction pathways.
Statements (61)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
lyase ⓘ membrane protein ⓘ |
| catalyzesReaction | ATP → cyclic AMP + pyrophosphate ⓘ |
| foundInTaxon |
Drosophila melanogaster
NERFINISHED
ⓘ
Escherichia coli NERFINISHED ⓘ Homo sapiens NERFINISHED ⓘ Mus musculus ⓘ |
| hasBiologicalProcess |
G-protein coupled receptor signaling pathway
ⓘ
cardiac muscle contraction ⓘ cyclic AMP biosynthetic process ⓘ glucagon signaling pathway ⓘ hormone-mediated signaling pathway ⓘ insulin secretion ⓘ learning and memory ⓘ olfactory signaling pathway ⓘ regulation of ion transport ⓘ regulation of metabolism ⓘ signal transduction ⓘ smooth muscle relaxation ⓘ visual phototransduction ⓘ |
| hasCellularComponent | integral component of membrane ⓘ |
| hasClinicalRelevance |
cardiomyopathy
ⓘ
drug addiction ⓘ endocrine disorders ⓘ heart failure ⓘ neurological disorders ⓘ type 2 diabetes mellitus NERFINISHED ⓘ |
| hasECNumber | EC 4.6.1.1 ⓘ |
| hasIsoform |
adenylyl cyclase type 1
ⓘ
adenylyl cyclase type 2 ⓘ adenylyl cyclase type 3 ⓘ adenylyl cyclase type 4 ⓘ adenylyl cyclase type 5 NERFINISHED ⓘ adenylyl cyclase type 6 NERFINISHED ⓘ adenylyl cyclase type 7 NERFINISHED ⓘ adenylyl cyclase type 8 ⓘ adenylyl cyclase type 9 ⓘ soluble adenylyl cyclase ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
adenylate cyclase activity ⓘ |
| hasSystematicName | ATP diphosphate-lyase (cyclizing) ⓘ |
| locatedIn |
membrane of intracellular organelles
ⓘ
plasma membrane ⓘ |
| partOf |
GPCR signaling cascade
ⓘ
adenylate cyclase-activating adrenergic receptor signaling pathway ⓘ adenylate cyclase-activating dopamine receptor signaling pathway ⓘ adenylate cyclase-activating glucagon receptor signaling pathway ⓘ cAMP signaling pathway NERFINISHED ⓘ |
| producesProduct |
cyclic AMP
ⓘ
pyrophosphate ⓘ |
| regulatedBy |
calcium ions
ⓘ
calmodulin NERFINISHED ⓘ cholera toxin via Gs activation ⓘ forskolin NERFINISHED ⓘ heterotrimeric G protein Gi alpha subunit ⓘ heterotrimeric G protein Gs alpha subunit ⓘ pertussis toxin via Gi inactivation ⓘ protein kinase A ⓘ protein kinase C ⓘ |
| usesSubstrate | ATP ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.