Gi-coupled GPCR
E874315
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
G protein–coupled receptor
ⓘ
membrane receptor ⓘ |
| activates |
Gi alpha subunit
ⓘ
Gi beta-gamma subunits ⓘ |
| associatedWith |
cancer
ⓘ
cardiovascular diseases ⓘ metabolic disorders ⓘ neurological disorders ⓘ |
| belongsToFamily | class A GPCR ⓘ |
| canActivate |
MAPK signaling pathway
ⓘ
PI3K-Akt signaling pathway ⓘ |
| canAlsoSignalVia | beta-arrestin–dependent pathways ⓘ |
| couplesTo |
Gi protein
ⓘ
heterotrimeric G protein ⓘ |
| downstreamEffect |
modulation of ion channel activity
ⓘ
reduced protein kinase A activity ⓘ regulation of gene transcription ⓘ |
| encodedBy | GPCR genes ⓘ |
| example |
D2 dopamine receptor
NERFINISHED
ⓘ
M2 muscarinic acetylcholine receptor NERFINISHED ⓘ alpha2-adrenergic receptor ⓘ chemokine receptor CCR5 ⓘ chemokine receptor CXCR4 NERFINISHED ⓘ opioid receptor ⓘ somatostatin receptor ⓘ |
| foundIn |
invertebrates
ⓘ
vertebrates ⓘ |
| hasEffectOn |
adenylyl cyclase inhibition
ⓘ
decrease in intracellular cAMP levels ⓘ |
| hasStructuralFeature | seven transmembrane helices ⓘ |
| involvedIn |
cardiovascular regulation
ⓘ
endocrine regulation ⓘ immune cell trafficking ⓘ neurotransmission ⓘ |
| isTargetOf | many therapeutic drugs ⓘ |
| ligandType |
chemokine
ⓘ
hormone ⓘ lipid mediator ⓘ neurotransmitter ⓘ |
| locatedIn | plasma membrane ⓘ |
| negativelyRegulates | cAMP production ⓘ |
| regulates | adenylyl cyclase activity ⓘ |
| requires | agonist binding for activation ⓘ |
| signalTransductionMechanism | G protein–dependent signaling ⓘ |
| subjectTo |
desensitization
ⓘ
downregulation ⓘ internalization ⓘ |
| undergoes | conformational change upon ligand binding ⓘ |
| uponActivation |
dissociates Gi alpha from beta-gamma complex
ⓘ
promotes GDP-GTP exchange on Gi alpha subunit ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.