CB1 receptor
E55578
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
Observed surface forms (1)
| Surface form | As subject | As object |
|---|---|---|
| CNR1 gene | 0 | 1 |
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
G protein–coupled receptor
→
cannabinoid receptor → membrane protein → |
| agonist |
2-arachidonoylglycerol
→
anandamide → Δ9-tetrahydrocannabinol → |
| antagonist |
SR141716A
→
rimonabant → |
| associatedWith |
metabolic syndrome
→
obesity → substance use disorders → |
| belongsToFamily | class A rhodopsin-like GPCRs → |
| bindsLigand |
2-arachidonoylglycerol
→
anandamide → synthetic cannabinoids → Δ9-tetrahydrocannabinol → |
| coupledTo |
Gi protein
→
Go protein → |
| discoveredBy | Lisa Matsuda → |
| discoveredIn | 1990 → |
| encodedBy |
CB1 receptor
self-linksurface differs
→
surface form:
CNR1 gene
|
| expressedHighlyIn |
basal ganglia
→
cerebellum → hippocampus → |
| foundIn |
basal ganglia
→
brain → central nervous system → cerebellum → cerebral cortex → hippocampus → peripheral nervous system → presynaptic nerve terminals → |
| hasEffect |
activation of inwardly rectifying potassium channels
→
inhibition of adenylyl cyclase → inhibition of voltage-gated calcium channels → reduction of neurotransmitter release → |
| hasTransmembraneDomains | 7 → |
| involvedIn |
anxiety regulation
→
appetite regulation → memory processes → motor control → pain modulation → reward pathways → |
| locatedIn | plasma membrane → |
| mediates | psychoactive effects of cannabis → |
| orthologFoundIn |
human
→
mouse → rat → |
| partOf | endocannabinoid system → |
| regulates |
GABA release
→
glutamate release → |
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
CNR1 gene