CB1 receptor
E55578
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
All labels observed (3)
| Label | Occurrences |
|---|---|
| CB1 receptor canonical | 4 |
| CB1 cannabinoid receptor | 1 |
| CNR1 gene | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T442845 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CB1 receptor Context triple: [Cannabis, primaryReceptorTarget, CB1 receptor]
-
A.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
-
B.
CBX
CBX is a pedestrian skybridge and terminal facility that connects San Diego directly to Tijuana International Airport, allowing ticketed passengers to cross the U.S.–Mexico border quickly and conveniently.
-
C.
Pinaroloxias
Pinaroloxias is a monotypic bird genus of Darwin’s finches, best known for the warbler finch endemic to the Galápagos Islands.
-
D.
Cannabis
Cannabis is a genus of flowering plants best known for producing psychoactive and medicinal compounds such as THC and CBD, widely used for recreational, therapeutic, and industrial (hemp) purposes.
-
E.
Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CB1 receptor Target entity description: The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
A.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
-
B.
CBX
CBX is a pedestrian skybridge and terminal facility that connects San Diego directly to Tijuana International Airport, allowing ticketed passengers to cross the U.S.–Mexico border quickly and conveniently.
-
C.
Pinaroloxias
Pinaroloxias is a monotypic bird genus of Darwin’s finches, best known for the warbler finch endemic to the Galápagos Islands.
-
D.
Cannabis
Cannabis is a genus of flowering plants best known for producing psychoactive and medicinal compounds such as THC and CBD, widely used for recreational, therapeutic, and industrial (hemp) purposes.
-
E.
Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
G protein–coupled receptor
ⓘ
cannabinoid receptor ⓘ membrane protein ⓘ |
| agonist |
2-arachidonoylglycerol
ⓘ
anandamide ⓘ Δ9-tetrahydrocannabinol ⓘ |
| antagonist |
SR141716A
ⓘ
rimonabant ⓘ |
| associatedWith |
metabolic syndrome
ⓘ
obesity ⓘ substance use disorders ⓘ |
| belongsToFamily | class A rhodopsin-like GPCRs ⓘ |
| bindsLigand |
2-arachidonoylglycerol
ⓘ
anandamide ⓘ synthetic cannabinoids ⓘ Δ9-tetrahydrocannabinol ⓘ |
| coupledTo |
Gi protein
ⓘ
Go protein ⓘ |
| discoveredBy | Lisa Matsuda ⓘ |
| discoveredIn | 1990 ⓘ |
| encodedBy |
CB1 receptor
self-linksurface differs
ⓘ
surface form:
CNR1 gene
|
| expressedHighlyIn |
basal ganglia
ⓘ
cerebellum ⓘ hippocampus ⓘ |
| foundIn |
basal ganglia
ⓘ
brain ⓘ central nervous system ⓘ cerebellum ⓘ cerebral cortex ⓘ hippocampus ⓘ peripheral nervous system ⓘ presynaptic nerve terminals ⓘ |
| hasEffect |
activation of inwardly rectifying potassium channels
ⓘ
inhibition of adenylyl cyclase ⓘ inhibition of voltage-gated calcium channels ⓘ reduction of neurotransmitter release ⓘ |
| hasTransmembraneDomains | 7 ⓘ |
| involvedIn |
anxiety regulation
ⓘ
appetite regulation ⓘ memory processes ⓘ motor control ⓘ pain modulation ⓘ reward pathways ⓘ |
| locatedIn | plasma membrane ⓘ |
| mediates | psychoactive effects of cannabis ⓘ |
| orthologFoundIn |
human
ⓘ
mouse ⓘ rat ⓘ |
| partOf | endocannabinoid system ⓘ |
| regulates |
GABA release
ⓘ
glutamate release ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CB1 receptor Description of subject: The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
CNR1 gene
this entity surface form:
CB1 cannabinoid receptor