endocannabinoid system
E275984
The endocannabinoid system is a widespread cell-signaling network in the body that helps regulate processes such as mood, appetite, pain, memory, and immune function through cannabinoid receptors, endogenous ligands, and metabolic enzymes.
All labels observed (1)
| Label | Occurrences |
|---|---|
| endocannabinoid system canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T2523548 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: endocannabinoid system Context triple: [CB1 receptor, partOf, endocannabinoid system]
-
A.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
B.
CBD
CBD is a non-intoxicating compound found in cannabis that is widely used for its potential therapeutic effects, such as reducing anxiety, pain, and inflammation.
-
C.
CBD
CBD is an international treaty adopted in 1992 that aims to conserve biological diversity, promote sustainable use of its components, and ensure fair and equitable sharing of benefits arising from genetic resources.
-
D.
PNS
PNS is the three-letter IATA airport code for Pensacola International Airport in Pensacola, Florida.
-
E.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: endocannabinoid system Target entity description: The endocannabinoid system is a widespread cell-signaling network in the body that helps regulate processes such as mood, appetite, pain, memory, and immune function through cannabinoid receptors, endogenous ligands, and metabolic enzymes.
-
A.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
B.
CBD
CBD is a non-intoxicating compound found in cannabis that is widely used for its potential therapeutic effects, such as reducing anxiety, pain, and inflammation.
-
C.
CBD
CBD is an international treaty adopted in 1992 that aims to conserve biological diversity, promote sustainable use of its components, and ensure fair and equitable sharing of benefits arising from genetic resources.
-
D.
PNS
PNS is the three-letter IATA airport code for Pensacola International Airport in Pensacola, Florida.
-
E.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
biological signaling system
ⓘ
physiological regulatory system ⓘ |
| component |
cannabinoid receptors
ⓘ
endogenous cannabinoids ⓘ metabolic enzymes ⓘ |
| discoveredIn | late 20th century ⓘ |
| endogenousLigand |
2-arachidonoylglycerol
ⓘ
anandamide ⓘ |
| foundIn |
human body
ⓘ
mammalian body ⓘ |
| function | maintenance of homeostasis ⓘ |
| hasPart |
2-arachidonoylglycerol
ⓘ
CB1 receptor ⓘ CB2 receptor ⓘ DAGL enzyme ⓘ FAAH enzyme ⓘ MAGL enzyme ⓘ NAPE-PLD enzyme ⓘ anandamide ⓘ |
| ligandOf |
CB1 receptor
ⓘ
CB2 receptor ⓘ |
| location |
adipose tissue
ⓘ
central nervous system ⓘ gastrointestinal tract ⓘ immune cells ⓘ liver ⓘ muscle tissue ⓘ peripheral nervous system ⓘ reproductive organs ⓘ skin ⓘ |
| modulatedBy |
cannabidiol
ⓘ
phytocannabinoids ⓘ synthetic cannabinoids ⓘ Δ9-tetrahydrocannabinol ⓘ |
| receptorType | G protein–coupled receptor system ⓘ |
| regulates |
appetite
ⓘ
energy balance ⓘ immune function ⓘ inflammation ⓘ memory processes ⓘ mood ⓘ pain perception ⓘ reward processing ⓘ sleep ⓘ stress response ⓘ |
| relatedTo | cannabis pharmacology ⓘ |
| signalingMode |
autocrine signaling
ⓘ
paracrine signaling ⓘ retrograde signaling ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: endocannabinoid system Description of subject: The endocannabinoid system is a widespread cell-signaling network in the body that helps regulate processes such as mood, appetite, pain, memory, and immune function through cannabinoid receptors, endogenous ligands, and metabolic enzymes.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.