DAGL enzyme
E874322
The DAGL enzyme is a key biosynthetic enzyme in the endocannabinoid system that produces the signaling lipid 2-arachidonoylglycerol (2-AG) from diacylglycerol.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
diacylglycerol lipase
ⓘ
enzyme ⓘ |
| associatedWith |
endocannabinoid signaling
ⓘ
energy homeostasis ⓘ inflammation regulation ⓘ neurodevelopment ⓘ pain modulation ⓘ retrograde signaling at synapses ⓘ synaptic plasticity ⓘ |
| catalyzes | conversion of diacylglycerol to 2-arachidonoylglycerol ⓘ |
| encodedBy |
DAGLA gene
ⓘ
DAGLB gene ⓘ |
| foundIn |
brain
ⓘ
central nervous system ⓘ |
| hasActivity | diacylglycerol lipase activity ⓘ |
| hasCofactor | requires access to membrane phospholipid-derived diacylglycerol ⓘ |
| hasFunction |
biosynthesis of 2-arachidonoylglycerol
ⓘ
hydrolysis of diacylglycerol ⓘ |
| hasIsoform |
DAGLα
ⓘ
DAGLβ ⓘ |
| hasPathway | 2-AG biosynthetic pathway ⓘ |
| influences |
neurotransmitter release
ⓘ
synaptic transmission ⓘ |
| inhibitedBy |
selective DAGL inhibitors
ⓘ
tetrahydrolipstatin (orlistat, weakly) NERFINISHED ⓘ |
| involvesProcess |
endocannabinoid biosynthesis
ⓘ
lipid signaling ⓘ retrograde endocannabinoid signaling at excitatory synapses ⓘ retrograde endocannabinoid signaling at inhibitory synapses ⓘ |
| localization |
neuronal dendrites
ⓘ
plasma membrane ⓘ |
| locatedAt | postsynaptic neuron membranes ⓘ |
| memberOf | serine hydrolase family ⓘ |
| opposes | monoacylglycerol lipase-mediated 2-AG degradation ⓘ |
| partOf | endocannabinoid system NERFINISHED ⓘ |
| produces | 2-arachidonoylglycerol ⓘ |
| product |
2-arachidonoylglycerol
ⓘ
free fatty acid ⓘ |
| regulates |
endocannabinoid tone
ⓘ
levels of 2-arachidonoylglycerol ⓘ |
| relatedTo | monoacylglycerol lipase ⓘ |
| requires | serine hydrolase catalytic machinery ⓘ |
| substrate | diacylglycerol ⓘ |
| taxon |
Homo sapiens
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ |
| upstreamOf |
CB1 receptor activation
ⓘ
CB2 receptor activation ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.