DAGL enzyme
E874322
The DAGL enzyme is a key biosynthetic enzyme in the endocannabinoid system that produces the signaling lipid 2-arachidonoylglycerol (2-AG) from diacylglycerol.
All labels observed (1)
| Label | Occurrences |
|---|---|
| DAGL enzyme canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10610194 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
Target entity: DAGL enzyme Context triple: [endocannabinoid system, hasPart, DAGL enzyme]
-
A.
ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
-
B.
aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
-
C.
cytochrome P450 reductase
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
-
D.
NADPH
NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
-
E.
Neogranadine
Neogranadine refers to an inhabitant or native of the former Republic of New Granada, a 19th-century state in northern South America that encompassed much of present-day Colombia and surrounding regions.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
Target entity: DAGL enzyme Target entity description: The DAGL enzyme is a key biosynthetic enzyme in the endocannabinoid system that produces the signaling lipid 2-arachidonoylglycerol (2-AG) from diacylglycerol.
-
A.
ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
-
B.
aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
-
C.
cytochrome P450 reductase
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
-
D.
NADPH
NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
-
E.
Neogranadine
Neogranadine refers to an inhabitant or native of the former Republic of New Granada, a 19th-century state in northern South America that encompassed much of present-day Colombia and surrounding regions.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
diacylglycerol lipase
ⓘ
enzyme ⓘ |
| associatedWith |
endocannabinoid signaling
ⓘ
energy homeostasis ⓘ inflammation regulation ⓘ neurodevelopment ⓘ pain modulation ⓘ retrograde signaling at synapses ⓘ synaptic plasticity ⓘ |
| catalyzes | conversion of diacylglycerol to 2-arachidonoylglycerol ⓘ |
| encodedBy |
DAGLA gene
ⓘ
DAGLB gene ⓘ |
| foundIn |
brain
ⓘ
central nervous system ⓘ |
| hasActivity | diacylglycerol lipase activity ⓘ |
| hasCofactor | requires access to membrane phospholipid-derived diacylglycerol ⓘ |
| hasFunction |
biosynthesis of 2-arachidonoylglycerol
ⓘ
hydrolysis of diacylglycerol ⓘ |
| hasIsoform |
DAGLα
ⓘ
DAGLβ ⓘ |
| hasPathway | 2-AG biosynthetic pathway ⓘ |
| influences |
neurotransmitter release
ⓘ
synaptic transmission ⓘ |
| inhibitedBy |
selective DAGL inhibitors
ⓘ
tetrahydrolipstatin (orlistat, weakly) NERFINISHED ⓘ |
| involvesProcess |
endocannabinoid biosynthesis
ⓘ
lipid signaling ⓘ retrograde endocannabinoid signaling at excitatory synapses ⓘ retrograde endocannabinoid signaling at inhibitory synapses ⓘ |
| localization |
neuronal dendrites
ⓘ
plasma membrane ⓘ |
| locatedAt | postsynaptic neuron membranes ⓘ |
| memberOf | serine hydrolase family ⓘ |
| opposes | monoacylglycerol lipase-mediated 2-AG degradation ⓘ |
| partOf | endocannabinoid system NERFINISHED ⓘ |
| produces | 2-arachidonoylglycerol ⓘ |
| product |
2-arachidonoylglycerol
ⓘ
free fatty acid ⓘ |
| regulates |
endocannabinoid tone
ⓘ
levels of 2-arachidonoylglycerol ⓘ |
| relatedTo | monoacylglycerol lipase ⓘ |
| requires | serine hydrolase catalytic machinery ⓘ |
| substrate | diacylglycerol ⓘ |
| taxon |
Homo sapiens
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ |
| upstreamOf |
CB1 receptor activation
ⓘ
CB2 receptor activation ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Subject: DAGL enzyme Description of subject: The DAGL enzyme is a key biosynthetic enzyme in the endocannabinoid system that produces the signaling lipid 2-arachidonoylglycerol (2-AG) from diacylglycerol.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.