MAGL enzyme
E874321
MAGL enzyme is a key serine hydrolase that terminates endocannabinoid signaling by hydrolyzing 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| MAGL | 0 |
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
serine hydrolase ⓘ |
| abbreviation | MAGL NERFINISHED ⓘ |
| associatedWith |
cancer progression
ⓘ
neurodegenerative diseases ⓘ neuroinflammation ⓘ pain modulation ⓘ |
| biologicalProcess |
eicosanoid precursor generation
ⓘ
endocannabinoid metabolism ⓘ lipid catabolic process ⓘ termination of endocannabinoid signaling ⓘ |
| catalyticActivity | monoacylglycerol + H2O → glycerol + fatty acid ⓘ |
| catalyticResidue | serine ⓘ |
| chromosomalLocation | human chromosome 3q21.3 ⓘ |
| cofactorRequirement | does not require cofactors ⓘ |
| drugTargetFor |
analgesic agents
ⓘ
anti-inflammatory agents ⓘ anticancer agents ⓘ neuroprotective agents ⓘ |
| ECNumber | 3.1.1.23 ⓘ |
| enzymeClass |
hydrolase
ⓘ
lipase ⓘ |
| family | α/β-hydrolase fold enzymes ⓘ |
| fullName | monoacylglycerol lipase NERFINISHED ⓘ |
| geneName | MGLL ⓘ |
| inhibitedBy |
JZL184
ⓘ
KML29 ⓘ MJN110 ⓘ URB602 ⓘ organophosphorus inhibitors ⓘ |
| localization |
cell membrane-associated
ⓘ
cytosol ⓘ |
| molecularWeight | approximately 33 kDa ⓘ |
| oligomericState | homodimer ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| pathway |
arachidonic acid metabolism
NERFINISHED
ⓘ
endocannabinoid signaling pathway ⓘ |
| primaryFunction | hydrolyzes monoacylglycerols ⓘ |
| product |
arachidonic acid
ⓘ
glycerol ⓘ |
| regulates |
2-arachidonoylglycerol levels
ⓘ
CB1 receptor signaling ⓘ CB2 receptor signaling ⓘ |
| substrate |
2-arachidonoylglycerol
ⓘ
monoacylglycerols ⓘ |
| systematicName | monoacylglycerol lipase (EC 3.1.1.23) NERFINISHED ⓘ |
| tissueExpression |
adipose tissue
ⓘ
brain ⓘ gastrointestinal tract ⓘ liver ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.