G protein–coupled receptors
E874314
integral membrane protein
membrane receptor
protein family
signal transduction protein
transmembrane receptor
G protein–coupled receptors are a large family of membrane proteins that detect extracellular signals and activate intracellular G proteins to regulate diverse physiological processes.
Statements (87)
| Predicate | Object |
|---|---|
| instanceOf |
integral membrane protein
ⓘ
membrane receptor ⓘ protein family ⓘ signal transduction protein ⓘ transmembrane receptor ⓘ |
| activates | heterotrimeric G proteins ⓘ |
| alsoKnownAs |
7TM receptors
ⓘ
GPCRs NERFINISHED ⓘ seven‑transmembrane receptors ⓘ |
| associatedWith |
cancer
ⓘ
cardiovascular diseases ⓘ inflammatory diseases ⓘ metabolic disorders ⓘ neurological disorders ⓘ |
| binds | heterotrimeric G proteins ⓘ |
| detects |
extracellular ligands
ⓘ
hormones ⓘ light (in opsins) ⓘ lipid mediators ⓘ neurotransmitters ⓘ odorants ⓘ peptides ⓘ tastants ⓘ |
| downstreamEffect |
IP3 and DAG production
ⓘ
MAPK pathway activation ⓘ cAMP level modulation ⓘ intracellular Ca2+ mobilization ⓘ ion channel regulation ⓘ |
| encodedBy | GPCR genes ⓘ |
| evolutionaryOrigin | ancient protein family ⓘ |
| foundIn |
animals
ⓘ
fungi ⓘ humans ⓘ invertebrates ⓘ plants ⓘ vertebrates ⓘ |
| hasApproximateCountInHumans | around 800 genes ⓘ |
| hasExample |
angiotensin II receptor
NERFINISHED
ⓘ
chemokine receptor ⓘ dopamine receptor ⓘ glucagon receptor ⓘ histamine receptor ⓘ metabotropic glutamate receptor ⓘ muscarinic acetylcholine receptor ⓘ opioid receptor ⓘ rhodopsin ⓘ serotonin receptor ⓘ β‑adrenergic receptor ⓘ |
| hasStructuralFeature |
extracellular N‑terminus
ⓘ
extracellular loops ⓘ intracellular C‑terminus ⓘ intracellular loops ⓘ seven transmembrane α‑helices ⓘ |
| hasSubfamily |
Class A rhodopsin‑like receptors
NERFINISHED
ⓘ
Class B secretin‑like receptors NERFINISHED ⓘ Class C glutamate receptors NERFINISHED ⓘ Class F frizzled receptors NERFINISHED ⓘ adhesion GPCRs ⓘ frizzled/taste2 receptors ⓘ olfactory receptors ⓘ |
| isTargetOf |
angiotensin receptor blockers
ⓘ
antihistamines ⓘ antipsychotics ⓘ beta‑blockers ⓘ many therapeutic drugs ⓘ opioid drugs ⓘ |
| locatedIn |
cell membrane
ⓘ
plasma membrane ⓘ |
| participatesIn |
cardiovascular regulation
ⓘ
cell signaling ⓘ hormone signaling ⓘ immune regulation ⓘ metabolic regulation ⓘ neurotransmission ⓘ sensory perception ⓘ signal transduction ⓘ |
| regulatedBy |
phosphorylation
ⓘ
β‑arrestins ⓘ |
| signalThrough |
G12/13 proteins
ⓘ
Gi/o proteins NERFINISHED ⓘ Gq/11 proteins ⓘ Gs proteins NERFINISHED ⓘ |
| supervisedBy | International Union of Basic and Clinical Pharmacology GPCR nomenclature committee NERFINISHED ⓘ |
| undergoes |
desensitization
ⓘ
downregulation ⓘ internalization ⓘ recycling ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.