Triple

Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).

Phrase: G protein–coupled receptors | Statement: [Harel Weinstein, researchInterest, G protein–coupled receptors]

Target entity: G protein–coupled receptors
Context triple: [Harel Weinstein, researchInterest, G protein–coupled receptors]

• A. G protein–coupled receptors chosen
  G protein–coupled receptors are a large family of membrane proteins that detect extracellular signals and activate intracellular G proteins to regulate diverse physiological processes.
• B. Gi-coupled GPCR
  A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
• C. The Physiology of Synapses
  The Physiology of Synapses is a seminal scientific monograph by neurophysiologist John Eccles that systematically explores the mechanisms of synaptic transmission in the nervous system.
• D. Gi protein
  Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
• E. M2 muscarinic acetylcholine receptor
  The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
• F. None of above.
• G. Unsure - the case is ambiguous/there is not enough information to decide.