Lewy bodies

E229729
intracytoplasmic inclusion neuropathological hallmark pathological protein aggregate

Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.

Try in SPARQL Jump to: Surface forms Statements Referenced by

All labels observed (4)

Label Occurrences
Lewy bodies canonical 2
Lewy body pathology 1
Lewy neurites 1

Statements (50)

Predicate Object
instanceOf intracytoplasmic inclusion ⓘ
neuropathological hallmark ⓘ
pathological protein aggregate ⓘ
associatedWith synucleinopathies ⓘ
associatedWithDisease Lewy body dementia ⓘ
surface form: Lewy body disease

Parkinson's disease ⓘ
Lewy body dementia ⓘ
surface form: Parkinson's disease dementia

REM sleep behavior disorder ⓘ
dementia with Lewy bodies ⓘ
multiple system atrophy ⓘ
associatedWithSymptom autonomic dysfunction ⓘ
cognitive impairment ⓘ
fluctuating cognition ⓘ
parkinsonism ⓘ
visual hallucinations ⓘ
characteristicOf Parkinson's disease ⓘ
dementia with Lewy bodies ⓘ
classifiedAs intraneuronal inclusion body ⓘ
composedOf alpha-synuclein ⓘ
lipids ⓘ
membranous organelle remnants ⓘ
neurofilament proteins ⓘ
ubiquitin ⓘ
discoveredBy Friedrich Heinrich Lewy ⓘ
firstDescribedIn 1912 ⓘ
foundIn amygdala ⓘ
autonomic nervous system ⓘ
central nervous system ⓘ
cerebral cortex ⓘ
locus coeruleus ⓘ
neurons ⓘ
substantia nigra ⓘ
hasMorphology dense core with pale halo ⓘ
eosinophilic cytoplasmic inclusion ⓘ
locatedInCellularRegion neuronal cytoplasm ⓘ
neuronal soma ⓘ
mayOccurIn neuronal processes ⓘ
namedAfter Friedrich Heinrich Lewy ⓘ
partOf Lewy bodies self-linksurface differs ⓘ
surface form: Lewy body pathology
pathologicalRole neuronal death ⓘ
neuronal dysfunction ⓘ
proteinComponent misfolded alpha-synuclein ⓘ
phosphorylated alpha-synuclein ⓘ
relatedToProcess impaired proteostasis ⓘ
neurodegeneration ⓘ
protein aggregation ⓘ
stainsWith alpha-synuclein immunohistochemistry ⓘ
eosin ⓘ
hematoxylin and eosin ⓘ
ubiquitin immunohistochemistry ⓘ

Referenced by (5)

Full triples — surface form annotated when it differs from this entity's canonical label.

Parkinson's disease → hasBiomarker → Lewy bodies ⓘ
Lewy bodies → partOf → Lewy bodies self-linksurface differs ⓘ
this entity surface form: Lewy body pathology
Lewy body dementia → hasCause → Lewy bodies ⓘ
Lewy body dementia → hasPathology → Lewy bodies ⓘ
this entity surface form: cortical Lewy bodies
Lewy body dementia → hasPathology → Lewy bodies ⓘ
this entity surface form: Lewy neurites