locus coeruleus
E804585
The locus coeruleus is a small brainstem nucleus that is the primary source of norepinephrine in the brain and plays key roles in arousal, attention, and stress responses.
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
anatomical structure
ⓘ
brainstem nucleus ⓘ noradrenergic nucleus ⓘ |
| activityCorrelatesWith | level of alertness ⓘ |
| activityIncreasesWith |
novel stimuli
ⓘ
stress ⓘ |
| associatedWithDisease |
Alzheimer's disease
NERFINISHED
ⓘ
Parkinson's disease NERFINISHED ⓘ anxiety disorders ⓘ attention-deficit/hyperactivity disorder ⓘ major depressive disorder ⓘ |
| bilaterallyPaired | true ⓘ |
| cellType | noradrenergic neurons ⓘ |
| containsPigment | neuromelanin ⓘ |
| degeneratesIn |
Alzheimer's disease
ⓘ
Parkinson's disease ⓘ |
| developsFrom | alar plate of the embryonic hindbrain ⓘ |
| firingPattern |
phasic bursts
ⓘ
tonic activity ⓘ |
| hasNeurotransmitter |
noradrenaline
ⓘ
norepinephrine ⓘ |
| isPrimarySourceOf | norepinephrine in the brain ⓘ |
| locatedIn |
brainstem
ⓘ
pons ⓘ |
| marker | tyrosine hydroxylase expression ⓘ |
| modulates |
sensory signal-to-noise ratio
ⓘ
synaptic plasticity ⓘ |
| nameLanguage | Latin ⓘ |
| nameMeans | blue spot ⓘ |
| partOf |
ascending reticular activating system
ⓘ
central nervous system ⓘ |
| playsRoleIn |
arousal
ⓘ
attention ⓘ autonomic regulation ⓘ cognitive control ⓘ memory modulation ⓘ pain modulation ⓘ sleep–wake regulation ⓘ stress response ⓘ vigilance ⓘ |
| projectsTo |
amygdala
ⓘ
cerebellum ⓘ cerebral cortex ⓘ hippocampus ⓘ hypothalamus ⓘ spinal cord ⓘ thalamus NERFINISHED ⓘ |
| receivesInputFrom |
hypothalamus
ⓘ
nucleus paragigantocellularis ⓘ periaqueductal gray NERFINISHED ⓘ prefrontal cortex ⓘ |
| situatedDorsalTo | rostral pons ⓘ |
| situatedLateralTo | fourth ventricle NERFINISHED ⓘ |
| visibleAs | bluish area in the pontine tegmentum ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.