Lewy body dementia

E248332
dementia neurodegenerative disease progressive brain disorder synucleinopathy

Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.

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All labels observed (5)

Label Occurrences
Lewy body dementia canonical 2
Lewy body disease 1
Parkinson disease dementia 1

Statements (72)

Predicate Object
instanceOf dementia ⓘ
neurodegenerative disease ⓘ
progressive brain disorder ⓘ
synucleinopathy ⓘ
affects brain ⓘ
cerebral cortex ⓘ
subcortical structures ⓘ
hasAlternativeName Lewy body dementia ⓘ
surface form: dementia with Lewy bodies
hasBiomarker abnormal alpha-synuclein pathology ⓘ
reduced dopamine transporter uptake in basal ganglia ⓘ
hasCause Lewy bodies ⓘ
abnormal alpha-synuclein aggregation ⓘ
abnormal protein deposits in the brain ⓘ
hasComorbidity Alzheimer-type amyloid plaques ⓘ
neurofibrillary tangles ⓘ
hasCoreFeature REM sleep behavior disorder ⓘ
fluctuating cognition with pronounced variations in attention and alertness ⓘ
recurrent visual hallucinations ⓘ
spontaneous parkinsonism ⓘ
hasCourse progressive ⓘ
hasDiagnosticCriterion dementia plus core clinical features ⓘ
hasOnset insidious ⓘ
hasPathology Lewy bodies ⓘ
surface form: Lewy neurites

Lewy bodies ⓘ
surface form: cortical Lewy bodies

subcortical Lewy bodies ⓘ
hasPrognosis chronic ⓘ
life-shortening ⓘ
hasRiskFactor Parkinson's disease ⓘ
surface form: Parkinson disease

REM sleep behavior disorder ⓘ
advanced age ⓘ
family history of Lewy body disease ⓘ
male sex ⓘ
hasSymptom Parkinsonian motor symptoms ⓘ
REM sleep behavior disorder ⓘ
anxiety ⓘ
apathy ⓘ
autonomic dysfunction ⓘ
bradykinesia ⓘ
cognitive decline ⓘ
constipation ⓘ
daytime sleepiness ⓘ
delusions ⓘ
dementia ⓘ
depression ⓘ
disorganized speech ⓘ
fluctuating alertness ⓘ
fluctuating cognition ⓘ
impaired attention ⓘ
impaired executive function ⓘ
orthostatic hypotension ⓘ
paranoia ⓘ
postural instability ⓘ
resting tremor ⓘ
rigidity ⓘ
sensitivity to antipsychotic medications ⓘ
urinary incontinence ⓘ
visual hallucinations ⓘ
visuospatial impairment ⓘ
hasTreatment cholinesterase inhibitors ⓘ
clonazepam for REM sleep behavior disorder ⓘ
levodopa for parkinsonism ⓘ
melatonin for REM sleep behavior disorder ⓘ
hasTreatmentConsideration avoid typical antipsychotics when possible ⓘ
use low-dose atypical antipsychotics with caution ⓘ
hasTypicalAgeOfOnset over 60 years ⓘ
isAssociatedWith Alzheimer disease pathology ⓘ
Parkinson's disease ⓘ
surface form: Parkinson disease dementia
isClassifiedBy DSM-5 ⓘ
International Classification of Diseases ⓘ
surface form: ICD-10
isDistinctFrom Alzheimer's disease ⓘ
surface form: Alzheimer disease

Lewy body dementia self-linksurface differs ⓘ
surface form: Parkinson disease dementia
wasFirstDescribedBy Kenji Kosaka ⓘ

Referenced by (6)

Full triples — surface form annotated when it differs from this entity's canonical label.

Robin Williams → diagnosedWith → Lewy body dementia ⓘ
Lewy bodies → associatedWithDisease → Lewy body dementia ⓘ
this entity surface form: Parkinson's disease dementia
Lewy bodies → associatedWithDisease → Lewy body dementia ⓘ
this entity surface form: Lewy body disease
Lewy body dementia → isDistinctFrom → Lewy body dementia self-linksurface differs ⓘ
this entity surface form: Parkinson disease dementia
Lewy body dementia → hasAlternativeName → Lewy body dementia ⓘ
this entity surface form: dementia with Lewy bodies
Mayor Tom Kane → diagnosedWith → Lewy body dementia ⓘ
subject surface form: Tom Kane