Alzheimer's disease
E20980
Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, and is the most common cause of dementia in older adults.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Alzheimer’s disease | 5 |
Statements (89)
| Predicate | Object |
|---|---|
| instanceOf |
dementia
ⓘ
neurodegenerative disease ⓘ progressive disease ⓘ |
| alsoKnownAs |
AD
ⓘ
Alzheimer disease ⓘ |
| associatedWith |
amyloid precursor protein processing abnormalities
ⓘ
presenilin 1 mutations ⓘ presenilin 2 mutations ⓘ |
| averageSurvivalAfterDiagnosis | 4 to 8 years ⓘ |
| canBeTreatedWith |
cholinesterase inhibitors
ⓘ
donepezil ⓘ galantamine ⓘ memantine ⓘ non-pharmacological interventions ⓘ rivastigmine ⓘ symptomatic therapies ⓘ |
| cause | multifactorial etiology ⓘ |
| characterizedBy |
behavioral changes
ⓘ
cognitive decline ⓘ impaired activities of daily living ⓘ memory loss ⓘ |
| course |
chronic
ⓘ
progressive ⓘ |
| diagnosedBy |
biomarker analysis
ⓘ
brain imaging ⓘ clinical assessment ⓘ neuropsychological testing ⓘ |
| diagnosticBiomarker |
cerebrospinal fluid amyloid-beta levels
ⓘ
cerebrospinal fluid tau levels ⓘ |
| diagnosticTool |
CT scan
ⓘ
MRI ⓘ PET scan ⓘ |
| epidemiology | most common cause of dementia worldwide ⓘ |
| field |
neurology
ⓘ
psychiatry ⓘ |
| governedByGuideline |
National Institute on Aging guidelines
ⓘ
World Health Organization dementia guidelines ⓘ |
| hasEarlyOnsetForm | early-onset Alzheimer's disease ⓘ |
| hasLateOnsetForm | late-onset Alzheimer's disease ⓘ |
| hasStage |
mild stage
ⓘ
moderate stage ⓘ severe stage ⓘ |
| hasSymptom |
agitation
ⓘ
apathy ⓘ delusions ⓘ disorientation ⓘ executive dysfunction ⓘ hallucinations ⓘ language difficulties ⓘ personality changes ⓘ short-term memory impairment ⓘ sleep disturbances ⓘ wandering ⓘ |
| impact |
caregiver burden
ⓘ
increased healthcare costs ⓘ loss of independence ⓘ |
| managementIncludes |
caregiver support
ⓘ
cognitive stimulation ⓘ environmental modifications ⓘ |
| namedAfter | Alois Alzheimer ⓘ |
| onsetTypicalAge | late adulthood ⓘ |
| pathologyFeature |
amyloid-beta plaques
ⓘ
brain atrophy ⓘ neurofibrillary tangles ⓘ neuronal loss ⓘ synaptic loss ⓘ tau protein aggregation ⓘ |
| prevalentIn | older adults ⓘ |
| preventionStrategy |
cardiovascular risk reduction
ⓘ
cognitive engagement ⓘ healthy diet ⓘ regular physical exercise ⓘ |
| primaryCauseOf | dementia in older adults ⓘ |
| prognosis |
eventually fatal
ⓘ
incurable ⓘ |
| riskFactor |
APOE ε4 allele
ⓘ
advanced age ⓘ cardiovascular disease ⓘ diabetes mellitus ⓘ family history of Alzheimer's disease ⓘ hypercholesterolemia ⓘ hypertension ⓘ low educational attainment ⓘ obesity ⓘ smoking ⓘ traumatic brain injury ⓘ |
| typicallyAffectsBrainRegion |
hippocampus
ⓘ
parietal lobe ⓘ temporal lobe ⓘ |
Referenced by (16)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Alzheimer’s disease
this entity surface form:
Alzheimer’s disease
this entity surface form:
Alzheimer’s disease
this entity surface form:
Alzheimer’s disease
this entity surface form:
Alzheimer’s disease