Alzheimer's disease

E20980
dementia neurodegenerative disease progressive disease

Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, and is the most common cause of dementia in older adults.

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All labels observed (4)

Label Occurrences
Alzheimer's disease canonical 33
Alzheimer’s disease 24
Alzheimer disease 1

Statements (89)

Predicate Object
instanceOf dementia ⓘ
neurodegenerative disease ⓘ
progressive disease ⓘ
alsoKnownAs AD ⓘ
Alzheimer disease ⓘ
associatedWith amyloid precursor protein processing abnormalities ⓘ
presenilin 1 mutations ⓘ
presenilin 2 mutations ⓘ
averageSurvivalAfterDiagnosis 4 to 8 years ⓘ
canBeTreatedWith cholinesterase inhibitors ⓘ
donepezil ⓘ
galantamine ⓘ
memantine ⓘ
non-pharmacological interventions ⓘ
rivastigmine ⓘ
symptomatic therapies ⓘ
cause multifactorial etiology ⓘ
characterizedBy behavioral changes ⓘ
cognitive decline ⓘ
impaired activities of daily living ⓘ
memory loss ⓘ
course chronic ⓘ
progressive ⓘ
diagnosedBy biomarker analysis ⓘ
brain imaging ⓘ
clinical assessment ⓘ
neuropsychological testing ⓘ
diagnosticBiomarker cerebrospinal fluid amyloid-beta levels ⓘ
cerebrospinal fluid tau levels ⓘ
diagnosticTool CT scan ⓘ
MRI ⓘ
PET scan ⓘ
epidemiology most common cause of dementia worldwide ⓘ
field neurology ⓘ
psychiatry ⓘ
governedByGuideline National Institute on Aging guidelines ⓘ
World Health Organization dementia guidelines ⓘ
hasEarlyOnsetForm early-onset Alzheimer's disease ⓘ
hasLateOnsetForm late-onset Alzheimer's disease ⓘ
hasStage mild stage ⓘ
moderate stage ⓘ
severe stage ⓘ
hasSymptom agitation ⓘ
apathy ⓘ
delusions ⓘ
disorientation ⓘ
executive dysfunction ⓘ
hallucinations ⓘ
language difficulties ⓘ
personality changes ⓘ
short-term memory impairment ⓘ
sleep disturbances ⓘ
wandering ⓘ
impact caregiver burden ⓘ
increased healthcare costs ⓘ
loss of independence ⓘ
managementIncludes caregiver support ⓘ
cognitive stimulation ⓘ
environmental modifications ⓘ
namedAfter Alois Alzheimer ⓘ
onsetTypicalAge late adulthood ⓘ
pathologyFeature amyloid-beta plaques ⓘ
brain atrophy ⓘ
neurofibrillary tangles ⓘ
neuronal loss ⓘ
synaptic loss ⓘ
tau protein aggregation ⓘ
prevalentIn older adults ⓘ
preventionStrategy cardiovascular risk reduction ⓘ
cognitive engagement ⓘ
healthy diet ⓘ
regular physical exercise ⓘ
primaryCauseOf dementia in older adults ⓘ
prognosis eventually fatal ⓘ
incurable ⓘ
riskFactor APOE ε4 allele ⓘ
advanced age ⓘ
cardiovascular disease ⓘ
diabetes mellitus ⓘ
family history of Alzheimer's disease ⓘ
hypercholesterolemia ⓘ
hypertension ⓘ
low educational attainment ⓘ
obesity ⓘ
smoking ⓘ
traumatic brain injury ⓘ
typicallyAffectsBrainRegion hippocampus ⓘ
parietal lobe ⓘ
temporal lobe ⓘ

Referenced by (59)

Full triples — surface form annotated when it differs from this entity's canonical label.

Picower Institute for Learning and Memory → fieldOfWork → Alzheimer's disease ⓘ
Biogen → focusesOn → Alzheimer's disease ⓘ
Department of Psychiatry, University of Cambridge → researchFocus → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Walter Brattain → causeOfDeath → Alzheimer's disease ⓘ
Katherine DeMille → causeOfDeath → Alzheimer's disease ⓘ
Leqembi → hasIndication → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Duke Institute for Brain Sciences → hasResearchFocus → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Neuroscience Program → researchArea → Alzheimer's disease ⓘ
Patti Davis → wroteAbout → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Urho Kekkonen → causeOfDeath → Alzheimer's disease ⓘ
Rita Hayworth → causeOfDeath → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Bob Paisley → causeOfDeath → Alzheimer's disease ⓘ
Harold Wilson → causeOfDeath → Alzheimer's disease ⓘ
Pat Summitt → causeOfDeath → Alzheimer's disease ⓘ
Rip Torn → causeOfDeath → Alzheimer's disease ⓘ
Emil Cioran → causeOfDeath → Alzheimer's disease ⓘ
Iris → portrays → Alzheimer's disease ⓘ
Albert Reynolds → causeOfDeath → Alzheimer's disease ⓘ
this entity surface form: Alzheimer's disease (complications)
Sargent Shriver → causeOfDeath → Alzheimer's disease ⓘ
Alois Alzheimer → eponymOf → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Charlton Heston → diagnosedWith → Alzheimer's disease ⓘ
CLARITY AD → conditionStudied → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Study 301 → indication → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Bill France Sr. was the first president of NASCAR → causeOfDeath → Alzheimer's disease ⓘ
subject surface form: Bill France Sr.
Eisai and Biogen → focusesOn → Alzheimer's disease ⓘ
subject surface form: Eisai
this entity surface form: Alzheimer’s disease
Eisai and Biogen → focusesOn → Alzheimer's disease ⓘ
subject surface form: Biogen
this entity surface form: Alzheimer’s disease
Eisai and Biogen → treats → Alzheimer's disease ⓘ
subject surface form: aducanumab
this entity surface form: Alzheimer’s disease
Eisai and Biogen → therapeuticArea → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Elan Pharmaceuticals → researchArea → Alzheimer's disease ⓘ
EMERGE (Study 302) → indication → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Donepezil → doesNotCure → Alzheimer's disease ⓘ
John Jay O’Connor III → causeOfDeath → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
George W. Beadle → causeOfDeath → Alzheimer's disease ⓘ
Hebrew SeniorLife → fieldOfWork → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Sugar Ray Robinson → causeOfDeath → Alzheimer's disease ⓘ
The Long Goodbye → mainSubject → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Beyond Alzheimer’s support group → focusesOn → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Mae Questel → causeOfDeath → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Margaret Rutherford → causeOfDeath → Alzheimer's disease ⓘ
Lou Ruvo Center for Brain Health → researchFocus → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Iris Murdoch → causeOfDeath → Alzheimer's disease ⓘ
Martin Peters → causeOfDeath → Alzheimer's disease ⓘ
A. E. van Vogt → causeOfDeath → Alzheimer's disease ⓘ
Catherine Scorsese → causeOfDeath → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Lewy body dementia → isDistinctFrom → Alzheimer's disease ⓘ
this entity surface form: Alzheimer disease
hippocampus → associatedWith → Alzheimer's disease ⓘ
Sanders-Brown Center on Aging → focusesOn → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease
Sylvia Woods → causeOfDeath → Alzheimer's disease ⓘ
Marion Brown → causeOfDeath → Alzheimer's disease ⓘ
Gladstone Institutes → hasResearchFocus → Alzheimer's disease ⓘ
this entity surface form: Alzheimer’s disease