APOE ε4 allele

E115305

allele genetic variant risk factor

The APOE ε4 allele is a genetic variant of the apolipoprotein E gene that significantly increases an individual's susceptibility to late-onset Alzheimer's disease.

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All labels observed (2)

Label	Occurrences
APOE ε4 allele canonical	2
apolipoprotein E4 isoform	1

Statements (51)

Predicate	Object
instanceOf	allele ⓘ genetic variant ⓘ risk factor ⓘ
associatedWith	atherosclerosis ⓘ cerebral amyloid angiopathy ⓘ cognitive decline ⓘ coronary artery disease ⓘ earlier age of onset of Alzheimer’s disease ⓘ hippocampal atrophy ⓘ increased amyloid-β deposition ⓘ increased low-density lipoprotein cholesterol ⓘ increased risk of Alzheimer’s disease ⓘ increased risk of cerebral microbleeds ⓘ increased risk of dementia with Lewy bodies ⓘ increased risk of intracerebral hemorrhage ⓘ increased risk of ischemic stroke ⓘ increased total cholesterol ⓘ late-onset Alzheimer’s disease ⓘ mild cognitive impairment ⓘ poorer memory performance in aging ⓘ poorer outcome after subarachnoid hemorrhage ⓘ poorer outcome after traumatic brain injury ⓘ sporadic Alzheimer’s disease ⓘ
definedBy	specific SNP combination at rs429358 and rs7412 ⓘ
differsFrom	APOE ε2 allele ⓘ APOE ε3 allele ⓘ
encodes	APOE ε4 allele self-linksurface differs ⓘ surface form: apolipoprotein E4 isoform
hasAminoAcidChange	arginine at positions 112 and 158 of apolipoprotein E ⓘ
hasEffect	increases risk of late-onset Alzheimer’s disease in a dose-dependent manner ⓘ lowers average age at onset of Alzheimer’s disease ⓘ one copy increases Alzheimer’s disease risk compared to non-carriers ⓘ two copies greatly increase Alzheimer’s disease risk compared to non-carriers ⓘ
hasFrequency	varies by population ⓘ
hasHigherFrequencyIn	people of Northern European ancestry ⓘ
hasInheritancePattern	autosomal ⓘ codominant ⓘ
hasLowerFrequencyIn	East Asia ⓘ surface form: East Asian populations some African populations ⓘ
hasRiskMagnitude	moderate to high for late-onset Alzheimer’s disease ⓘ
influences	amyloid-β aggregation ⓘ amyloid-β clearance ⓘ lipid transport in the brain ⓘ neuroinflammation ⓘ synaptic function ⓘ tau pathology progression ⓘ
isDetectedBy	genetic testing ⓘ
locatedIn	APOE gene locus 19q13.32 ⓘ
locatedOn	chromosome 19 ⓘ
modifies	response to Alzheimer’s disease pathology ⓘ
partOf	APOE gene ⓘ
usedIn	Alzheimer’s disease risk stratification in research settings ⓘ

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

Alzheimer's disease → riskFactor → APOE ε4 allele ⓘ

APOE ε4 allele → encodes → APOE ε4 allele self-linksurface differs ⓘ

this entity surface form: apolipoprotein E4 isoform

ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) → riskFactor → APOE ε4 allele ⓘ

subject surface form: ARIA-H