APOE gene
E494100
The APOE gene encodes apolipoprotein E, a key protein in lipid metabolism whose variants, especially ε4, strongly influence risk for Alzheimer’s disease and cardiovascular disorders.
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf | protein-coding gene ⓘ |
| APOEε2AssociatedWith |
increased risk of type III hyperlipoproteinemia
ⓘ
reduced risk of Alzheimer’s disease ⓘ |
| APOEε4AssociatedWith |
earlier age of onset of Alzheimer’s disease
ⓘ
increased LDL cholesterol levels ⓘ increased amyloid-β deposition ⓘ increased cardiovascular risk ⓘ increased risk of Alzheimer’s disease ⓘ |
| associatedWithDisease |
Alzheimer’s disease
NERFINISHED
ⓘ
atherosclerosis ⓘ cardiovascular disease ⓘ cerebral amyloid angiopathy ⓘ coronary artery disease ⓘ hyperlipoproteinemia type III ⓘ late-onset Alzheimer’s disease ⓘ |
| biologicalProcess |
cholesterol homeostasis
ⓘ
lipid transport ⓘ lipoprotein metabolic process ⓘ |
| cellularComponent |
extracellular region
ⓘ
plasma lipoprotein particle ⓘ |
| chromosomalBand | 19q13.32 ⓘ |
| clinicalUse |
genetic marker in cardiovascular risk assessment
ⓘ
genetic risk marker for Alzheimer’s disease ⓘ |
| encodes | apolipoprotein E NERFINISHED ⓘ |
| encodesProtein | apolipoprotein E precursor NERFINISHED ⓘ |
| EnsemblID | ENSG00000130203 ⓘ |
| EntrezGeneID | 348 ⓘ |
| expressedInCellType |
astrocytes
ⓘ
microglia ⓘ |
| expressedInTissue |
brain
ⓘ
liver ⓘ |
| foundInSpecies | Homo sapiens NERFINISHED ⓘ |
| hasAlias |
AD2
ⓘ
APO-E NERFINISHED ⓘ APOE NERFINISHED ⓘ Apo-E gene NERFINISHED ⓘ Apolipoprotein E gene NERFINISHED ⓘ LDLCQ5 ⓘ |
| hasAllele |
APOE ε2
NERFINISHED
ⓘ
APOE ε3 NERFINISHED ⓘ APOE ε4 NERFINISHED ⓘ |
| HGNCID | HGNC:613 ⓘ |
| locatedOnChromosome | chromosome 19 ⓘ |
| molecularFunction |
cholesterol transporter activity
ⓘ
lipoprotein particle receptor binding ⓘ |
| mostCommonAllele | APOE ε3 NERFINISHED ⓘ |
| protectiveAlleleForDisease | APOE ε2 NERFINISHED ⓘ |
| proteinProductInteractsWith |
LDL receptor
NERFINISHED
ⓘ
LDL receptor–related protein 1 NERFINISHED ⓘ |
| proteinProductParticipatesIn |
clearance of chylomicron remnants
ⓘ
clearance of very-low-density lipoproteins ⓘ |
| regulationRole | influences neuronal repair and plasticity via lipid transport ⓘ |
| riskAlleleForDisease | APOE ε4 NERFINISHED ⓘ |
| UniProtProteinEncoded | P02649 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.