ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits)
E125385
ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) is a brain MRI finding characterized by small cerebral microbleeds and hemosiderin accumulation, typically associated with anti-amyloid therapies for Alzheimer’s disease.
All labels observed (1)
| Label | Occurrences |
|---|---|
| ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T1103722 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) Context triple: [Leqembi, hasCommonAdverseEffect, ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits)]
-
A.
Hipple
Hipple is the birth surname of American film and television actor Hugh Marlowe.
-
B.
MCI-Shirley
MCI-Shirley is a medium- and minimum-security state prison for men located in Shirley, Massachusetts.
-
C.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
-
D.
BHD
BHD is the IATA airport code for George Best Belfast City Airport, a major regional airport serving Belfast, Northern Ireland.
-
E.
Aduhelm
Aduhelm is an Alzheimer’s disease drug developed by Biogen that targets amyloid-beta plaques in the brain.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) Target entity description: ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) is a brain MRI finding characterized by small cerebral microbleeds and hemosiderin accumulation, typically associated with anti-amyloid therapies for Alzheimer’s disease.
-
A.
Hipple
Hipple is the birth surname of American film and television actor Hugh Marlowe.
-
B.
MCI-Shirley
MCI-Shirley is a medium- and minimum-security state prison for men located in Shirley, Massachusetts.
-
C.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
-
D.
BHD
BHD is the IATA airport code for George Best Belfast City Airport, a major regional airport serving Belfast, Northern Ireland.
-
E.
Aduhelm
Aduhelm is an Alzheimer’s disease drug developed by Biogen that targets amyloid-beta plaques in the brain.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
amyloid-related imaging abnormality
ⓘ
radiologic finding ⓘ |
| abbreviationFor | amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits ⓘ |
| associatedWith |
Alzheimer's disease
ⓘ
Aduhelm ⓘ
surface form:
aducanumab
anti-amyloid therapy ⓘ cerebral amyloid angiopathy ⓘ Leqembi ⓘ
surface form:
donanemab
Leqembi ⓘ
surface form:
lecanemab
monoclonal antibodies targeting beta-amyloid ⓘ |
| canBeAsymptomatic | true ⓘ |
| canCauseSymptom |
confusion
ⓘ
focal neurological deficits ⓘ headache ⓘ seizures ⓘ |
| distinguishedFrom | ARIA-E ⓘ |
| firstDescribedInContextOf | clinical trials of anti-amyloid therapies for Alzheimer's disease ⓘ |
| fullName | amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits ⓘ |
| hasCourse | may stabilize or progress with continued exposure to anti-amyloid therapy ⓘ |
| hasFeature |
cerebral microbleeds
ⓘ
hemosiderin deposits ⓘ lobar microhemorrhages ⓘ punctate hypointense lesions on susceptibility-sensitive sequences ⓘ superficial siderosis ⓘ |
| hasImagingModality | magnetic resonance imaging ⓘ |
| hasLateralityPattern | often multifocal and bilateral ⓘ |
| hasPathophysiology |
microhemorrhage and hemosiderin deposition around amyloid-laden vessels
ⓘ
vascular fragility due to amyloid-laden vessels ⓘ |
| hasTypicalSequence |
T2*-weighted MRI
ⓘ
gradient-echo MRI ⓘ susceptibility-weighted imaging ⓘ |
| isPartOf | amyloid-related imaging abnormalities ⓘ |
| isSubtypeOf |
cerebral microhemorrhage
ⓘ
treatment-emergent imaging abnormality ⓘ |
| managementIncludes |
dose reduction of anti-amyloid therapy
ⓘ
permanent discontinuation of anti-amyloid therapy in severe cases ⓘ temporary interruption of anti-amyloid therapy ⓘ |
| monitoredBy | serial brain MRI ⓘ |
| occursIn |
cerebellum
ⓘ
cerebral cortex ⓘ leptomeninges ⓘ subcortical white matter ⓘ |
| requiresDifferentialDiagnosisWith |
cerebral amyloid angiopathy without treatment
ⓘ
hypertensive microbleeds ⓘ other causes of cerebral microhemorrhages ⓘ |
| riskFactor |
APOE ε4 allele
ⓘ
advanced age ⓘ higher doses of anti-amyloid antibodies ⓘ pre-existing cerebral microbleeds ⓘ |
| temporalRelationToTreatment | treatment-emergent during anti-amyloid therapy ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) Description of subject: ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits) is a brain MRI finding characterized by small cerebral microbleeds and hemosiderin accumulation, typically associated with anti-amyloid therapies for Alzheimer’s disease.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
Leqembi
→
hasCommonAdverseEffect
→
ARIA-H (amyloid-related imaging abnormalities with microhemorrhages and hemosiderin deposits)
ⓘ