Parkinson's disease
E44560
central nervous system disorder
chronic disease
movement disorder
neurodegenerative disease
progressive disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
Observed surface forms (3)
| Surface form | Occurrences |
|---|---|
| Parkinson’s disease | 2 |
| Parkinson disease | 1 |
| early-onset Parkinson's disease | 1 |
Statements (76)
| Predicate | Object |
|---|---|
| instanceOf |
central nervous system disorder
ⓘ
chronic disease ⓘ movement disorder ⓘ neurodegenerative disease ⓘ progressive disease ⓘ |
| affectsAnatomicalStructure |
basal ganglia
ⓘ
nigrostriatal pathway ⓘ substantia nigra ⓘ |
| hasBiomarker |
Lewy bodies
ⓘ
alpha-synuclein aggregates ⓘ |
| hasCause |
dopamine deficiency in the striatum
ⓘ
loss of dopaminergic neurons in the substantia nigra pars compacta ⓘ |
| hasComplication |
aspiration pneumonia
ⓘ
disability ⓘ falls ⓘ fractures ⓘ |
| hasCourse | gradually progressive ⓘ |
| hasDiagnosticMethod |
clinical examination
ⓘ
response to dopaminergic therapy ⓘ |
| hasDiagnosticSupport | DaTscan imaging ⓘ |
| hasEpidemiology |
more common in older adults
ⓘ
second most common neurodegenerative disease after Alzheimer's disease ⓘ |
| hasGeneticAssociation |
DJ-1 gene mutations
ⓘ
LRRK2 gene mutations ⓘ PARK2 (parkin) gene mutations ⓘ PINK1 gene mutations ⓘ SNCA gene mutations ⓘ |
| hasHistoricalName | paralysis agitans ⓘ |
| hasOnset | typically after age 60 ⓘ |
| hasPreclinicalFeature |
REM sleep behavior disorder
ⓘ
constipation ⓘ hyposmia ⓘ |
| hasRiskFactor |
advanced age
ⓘ
exposure to pesticides ⓘ family history of Parkinson's disease ⓘ male sex ⓘ rural living ⓘ |
| hasSubtype |
Parkinson's disease
self-linksurface differs
ⓘ
surface form:
early-onset Parkinson's disease
juvenile Parkinsonism ⓘ |
| hasSymptom |
REM sleep behavior disorder
ⓘ
anosmia ⓘ anxiety ⓘ autonomic dysfunction ⓘ bradykinesia ⓘ cognitive impairment ⓘ constipation ⓘ dementia ⓘ depression ⓘ drooling ⓘ dysphagia ⓘ fatigue ⓘ freezing of gait ⓘ hypophonia ⓘ masked facies ⓘ micrographia ⓘ orthostatic hypotension ⓘ postural instability ⓘ resting tremor ⓘ rigidity ⓘ shuffling gait ⓘ sleep disturbances ⓘ stooped posture ⓘ urinary dysfunction ⓘ |
| hasTreatment |
COMT inhibitors
ⓘ
MAO-B inhibitors ⓘ amantadine ⓘ anticholinergic drugs ⓘ carbidopa-levodopa combination ⓘ deep brain stimulation ⓘ dopamine agonists ⓘ levodopa ⓘ occupational therapy ⓘ physical therapy ⓘ speech therapy ⓘ |
| isPartOf | parkinsonian syndromes ⓘ |
| namedAfter | James Parkinson ⓘ |
Referenced by (11)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Parkinson disease
this entity surface form:
Parkinson’s disease
this entity surface form:
Parkinson’s disease
this entity surface form:
early-onset Parkinson's disease