alpha-synuclein
E804584
Alpha-synuclein is a neuronal protein whose abnormal aggregation is a hallmark of Parkinson’s disease and related synucleinopathies.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
neuronal protein
ⓘ
protein ⓘ |
| aggregationState |
forms amyloid fibrils
ⓘ
forms oligomers ⓘ |
| alsoKnownAs |
NACP
NERFINISHED
ⓘ
PARK1 protein NERFINISHED ⓘ non-Aβ component of Alzheimer disease amyloid NERFINISHED ⓘ α-synuclein ⓘ |
| aminoAcidLength | 140 amino acids ⓘ |
| associatedWithDisease |
Parkinson's disease
NERFINISHED
ⓘ
dementia with Lewy bodies ⓘ multiple system atrophy NERFINISHED ⓘ synucleinopathies ⓘ |
| bindsTo |
phospholipid membranes
ⓘ
synaptic vesicles ⓘ |
| cellularLocation |
cytosol
ⓘ
presynaptic terminal ⓘ synaptic vesicle membrane ⓘ |
| encodedBy | SNCA gene NERFINISHED ⓘ |
| expressedIn |
central nervous system
NERFINISHED
ⓘ
neurons ⓘ |
| foundInOrganism | Homo sapiens NERFINISHED ⓘ |
| geneticVariantAssociatedWithDisease |
A30P mutation
NERFINISHED
ⓘ
A53T mutation ⓘ E46K mutation ⓘ G51D mutation ⓘ H50Q mutation ⓘ SNCA gene duplication ⓘ SNCA gene triplication ⓘ |
| inclusionBodyComponentOf |
Lewy bodies
NERFINISHED
ⓘ
glial cytoplasmic inclusions in multiple system atrophy ⓘ |
| misfoldingConsequence |
impairment of autophagy-lysosomal pathway
ⓘ
impairment of proteasome function ⓘ mitochondrial dysfunction ⓘ neuronal toxicity ⓘ |
| molecularWeight | ~14 kDa ⓘ |
| normalFunction |
SNARE complex assembly modulation
ⓘ
regulation of neurotransmitter release ⓘ regulation of synaptic vesicle trafficking ⓘ |
| pathologicalFeature |
forms Lewy bodies
ⓘ
forms Lewy neurites ⓘ |
| postTranslationalModification |
nitration
ⓘ
phosphorylation at serine-129 ⓘ truncation ⓘ ubiquitination ⓘ |
| structureProperty |
adopts alpha-helical structure upon membrane binding
ⓘ
intrinsically disordered in solution ⓘ |
| subcellularProcessInvolvedIn |
dopamine neurotransmission
ⓘ
synaptic plasticity ⓘ |
| toxicForm | soluble oligomers ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.