pathogenicMechanism

P68675
predicate

Indicates the specific biological process or mechanism through which an agent causes disease or pathological effects in a host.

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All labels observed (9)

Label Occurrences
pathogenicMechanism canonical 8
oncogenicMechanism 4
diseaseMechanism 1

Description generation (PDg)

The one-sentence description above was generated by prompting gpt-5.1 with the predicate name and this instruction.

Instruction
Given a predicate that represents a relationship or action between entities, generate a one-sentence description explaining its meaning.  
# Instructions
Focus on describing the relationship, not the entities themselves. 
# Response Format
Begin the description with \' Indicates...\'
Input
Predicate: pathogenicMechanism
Generated description
Indicates the specific biological process or mechanism through which an agent causes disease or pathological effects in a host.

Sample triples (19)

Subject Object
C9orf72 haploinsufficiency ⓘ
C9orf72 RNA toxicity ⓘ
C9orf72 dipeptide repeat protein toxicity ⓘ
Legionella bacteria
surface form: Legionella
type IV secretion system via predicate surface "virulenceMechanism" ⓘ
Yersiniaceae type III secretion system in some genera ⓘ
Brugia timori lymphatic vessel infection via predicate surface "pathogenesis" ⓘ
Ancylostomatidae blood loss from intestinal mucosa ⓘ
Ancylostomatidae damage to intestinal mucosa ⓘ
Schistosomatidae immune response to deposited eggs via predicate surface "pathologyMechanism" ⓘ
CDK4 gene amplification via predicate surface "oncogenicMechanism" ⓘ
CDK4 activating mutation via predicate surface "oncogenicMechanism" ⓘ
CDK4 overexpression via predicate surface "oncogenicMechanism" ⓘ
EWSR1 chromosomal translocation via predicate surface "oncogenicMechanism" ⓘ
John Cunningham virus lytic infection of oligodendrocytes leading to demyelination via predicate surface "pathogenesisFeature" ⓘ
Naegleria fowleri destruction of brain tissue ⓘ
Naegleria fowleri induction of inflammation in the central nervous system ⓘ
HD
surface form: Huntington's disease
toxic gain of function of mutant huntingtin protein via predicate surface "hasPathogenesis" ⓘ
HTT gene
surface form: HTT
neurodegeneration of medium spiny neurons via predicate surface "pathogenicMechanismInDisease" ⓘ
Pectobacterium degradation of plant cell walls via predicate surface "diseaseMechanism" ⓘ