pathogenicMechanism
P68675
predicate
Indicates the specific biological process or mechanism through which an agent causes disease or pathological effects in a host.
Observed surface forms (8)
- oncogenicMechanism ×4
- diseaseMechanism ×1
- hasPathogenesis ×1
- pathogenesis ×1
- pathogenesisFeature ×1
- pathogenicMechanismInDisease ×1
- pathologyMechanism ×1
- virulenceMechanism ×1
Sample triples (19)
| Subject | Object |
|---|---|
| Ancylostomatidae | blood loss from intestinal mucosa ⓘ |
| Ancylostomatidae | damage to intestinal mucosa ⓘ |
| Brugia timori | lymphatic vessel infection via predicate surface "pathogenesis" ⓘ |
| C9orf72 | RNA toxicity ⓘ |
| C9orf72 | dipeptide repeat protein toxicity ⓘ |
| C9orf72 | haploinsufficiency ⓘ |
| CDK4 | activating mutation via predicate surface "oncogenicMechanism" ⓘ |
| CDK4 | gene amplification via predicate surface "oncogenicMechanism" ⓘ |
| CDK4 | overexpression via predicate surface "oncogenicMechanism" ⓘ |
| EWSR1 | chromosomal translocation via predicate surface "oncogenicMechanism" ⓘ |
|
HTT gene
surface form:
HTT
|
neurodegeneration of medium spiny neurons via predicate surface "pathogenicMechanismInDisease" ⓘ |
|
HD
surface form:
Huntington's disease
|
toxic gain of function of mutant huntingtin protein via predicate surface "hasPathogenesis" ⓘ |
| John Cunningham virus | lytic infection of oligodendrocytes leading to demyelination via predicate surface "pathogenesisFeature" ⓘ |
|
Legionella bacteria
surface form:
Legionella
|
type IV secretion system via predicate surface "virulenceMechanism" ⓘ |
| Naegleria fowleri | destruction of brain tissue ⓘ |
| Naegleria fowleri | induction of inflammation in the central nervous system ⓘ |
| Pectobacterium | degradation of plant cell walls via predicate surface "diseaseMechanism" ⓘ |
| Schistosomatidae | immune response to deposited eggs via predicate surface "pathologyMechanism" ⓘ |
| Yersiniaceae | type III secretion system in some genera ⓘ |