CDK4
E561032
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
cyclin-dependent kinase
ⓘ
human gene ⓘ protein kinase ⓘ |
| alternativeName |
PSK-J3
NERFINISHED
ⓘ
cell division protein kinase 4 NERFINISHED ⓘ |
| associatedWithDisease |
breast cancer
ⓘ
glioblastoma ⓘ liposarcoma ⓘ melanoma ⓘ non-small cell lung cancer NERFINISHED ⓘ |
| biologicalProcess |
G1 phase of mitotic cell cycle
ⓘ
G1/S transition of mitotic cell cycle ⓘ cell cycle checkpoint regulation ⓘ negative regulation of cell cycle arrest ⓘ phosphorylation of RB1 protein ⓘ regulation of cell proliferation ⓘ |
| cellularComponent |
cyclin-dependent protein kinase holoenzyme complex
ⓘ
cytoplasm ⓘ nucleus ⓘ |
| chromosomalBand | 12q14 ⓘ |
| clinicalBiomarkerRole | predictive biomarker for CDK4/6 inhibitor response ⓘ |
| conservedIn |
Danio rerio
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ Rattus norvegicus NERFINISHED ⓘ |
| encodedByGene | CDK4 gene NERFINISHED ⓘ |
| enzymeCommissionNumber | EC 2.7.11.22 ⓘ |
| formsComplexWith |
cyclin D1
ⓘ
cyclin D2 NERFINISHED ⓘ cyclin D3 ⓘ |
| fullName | cyclin-dependent kinase 4 NERFINISHED ⓘ |
| geneType | protein-coding gene ⓘ |
| hasEnsemblGeneID | ENSG00000135446 ⓘ |
| hasEntrezGeneID | 1019 ⓘ |
| hasHGNCID | HGNC:1773 ⓘ |
| hasUniProtID | P11802 ⓘ |
| inhibitedByDrug |
abemaciclib
NERFINISHED
ⓘ
lenvatinib (weak off-target) ⓘ palbociclib NERFINISHED ⓘ ribociclib NERFINISHED ⓘ trilaciclib NERFINISHED ⓘ |
| locatedOnChromosome | human chromosome 12 ⓘ |
| molecularFunction |
ATP binding
ⓘ
cyclin-dependent protein serine/threonine kinase activity ⓘ serine/threonine protein kinase activity ⓘ |
| oncogenicMechanism |
activating mutation
ⓘ
gene amplification ⓘ overexpression ⓘ |
| organism | Homo sapiens ⓘ |
| pathway |
G1/S transition pathway
ⓘ
cell cycle pathway ⓘ p16INK4A-CDK4-RB pathway ⓘ |
| postTranslationalModification | phosphorylation at threonine 172 ⓘ |
| regulatedBy |
CDKN2A (p16INK4A)
NERFINISHED
ⓘ
CDKN2B (p15INK4B) NERFINISHED ⓘ CDKN2C (p18INK4C) NERFINISHED ⓘ CDKN2D (p19INK4D) NERFINISHED ⓘ |
| requiresBindingPartner | D-type cyclins ⓘ |
| requiresCofactor | Mg2+ ⓘ |
| roleInCancerBiology |
drives cell cycle progression from G1 to S phase
ⓘ
promotes tumor cell proliferation when deregulated ⓘ |
| substrate |
RB1
NERFINISHED
ⓘ
RBL1 NERFINISHED ⓘ RBL2 NERFINISHED ⓘ |
| therapeuticTargetIn |
advanced breast cancer
ⓘ
hormone receptor-positive breast cancer ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.