EWSR1
E561108
EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
RNA-binding protein
ⓘ
gene ⓘ oncoprotein ⓘ protein ⓘ |
| alias |
EWS
NERFINISHED
ⓘ
Ewing sarcoma breakpoint region 1 NERFINISHED ⓘ |
| associatedWith | phase separation and ribonucleoprotein granule formation ⓘ |
| bindsMolecule |
RNA
ⓘ
single-stranded DNA ⓘ |
| biologicalProcess |
DNA damage response
ⓘ
RNA processing ⓘ cell differentiation ⓘ mRNA splicing ⓘ pre-mRNA processing ⓘ transcription regulation ⓘ |
| canonicalFusion | EWSR1–FLI1 NERFINISHED ⓘ |
| canonicalFusionAssociatedDisease | Ewing sarcoma NERFINISHED ⓘ |
| chromosomalBand | 22q12 ⓘ |
| family | FET protein family NERFINISHED ⓘ |
| familyMemberWith |
FUS
NERFINISHED
ⓘ
TAF15 NERFINISHED ⓘ |
| formsFusionWith |
ATF1
NERFINISHED
ⓘ
CREB1 NERFINISHED ⓘ DDIT3 NERFINISHED ⓘ ERG NERFINISHED ⓘ FLI1 NERFINISHED ⓘ NR4A3 ⓘ WT1 NERFINISHED ⓘ |
| fullName | EWS RNA-binding protein 1 NERFINISHED ⓘ |
| geneID | NCBI Gene 2130 ⓘ |
| geneType | protein-coding gene ⓘ |
| interactsWith |
RNA polymerase II
NERFINISHED
ⓘ
splicing factors ⓘ |
| involvedInDisease |
Ewing sarcoma
NERFINISHED
ⓘ
acute myeloid leukemia ⓘ clear cell sarcoma ⓘ desmoplastic small round cell tumor ⓘ extraskeletal myxoid chondrosarcoma ⓘ myxoid liposarcoma ⓘ myxoid round cell liposarcoma NERFINISHED ⓘ |
| locatedOnChromosome | human chromosome 22 ⓘ |
| molecularFunction |
DNA binding
ⓘ
RNA binding ⓘ transcriptional coactivator activity ⓘ |
| oncogenicMechanism | chromosomal translocation ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| participatesIn | formation of aberrant transcription factors in cancer ⓘ |
| pathway |
RNA metabolism
ⓘ
transcription-coupled RNA processing ⓘ |
| postTranslationalModification |
arginine methylation
ⓘ
phosphorylation ⓘ |
| proteinDomain |
C-terminal RNA recognition motif
ⓘ
N-terminal low-complexity prion-like domain ⓘ RGG-rich regions ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
| uniprotID | P35663 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.