FUS
E133686
FUS is a DNA/RNA-binding protein whose mutations are implicated in neurodegenerative diseases, particularly certain forms of amyotrophic lateral sclerosis (ALS).
All labels observed (3)
| Label | Occurrences |
|---|---|
| FUS canonical | 1 |
| FUS gene | 1 |
| fused in sarcoma | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T1169537 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: FUS Context triple: [ALS, associatedWithGene, FUS]
-
A.
FÜ
FÜ is the vehicle registration code used on license plates for the city of Fürth in Bavaria, Germany.
-
B.
FAS
FAS is a common abbreviation for the Faculty of Arts and Science, an academic division that typically encompasses a wide range of humanities, social science, and natural science disciplines at a university.
-
C.
Fink
Fink is an open-source package management system that brings a wide range of Unix and open-source software to macOS by compiling and distributing it in a convenient, Debian-like format.
-
D.
Fink
Fink is a British singer-songwriter and producer known for his atmospheric blend of folk, blues, and electronic music.
-
E.
FED
FED is the commonly used abbreviation for the Fluids Engineering Division, a professional group focused on research and advancements in fluid mechanics and related technologies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: FUS Target entity description: FUS is a DNA/RNA-binding protein whose mutations are implicated in neurodegenerative diseases, particularly certain forms of amyotrophic lateral sclerosis (ALS).
-
A.
FÜ
FÜ is the vehicle registration code used on license plates for the city of Fürth in Bavaria, Germany.
-
B.
FAS
FAS is a common abbreviation for the Faculty of Arts and Science, an academic division that typically encompasses a wide range of humanities, social science, and natural science disciplines at a university.
-
C.
Fink
Fink is an open-source package management system that brings a wide range of Unix and open-source software to macOS by compiling and distributing it in a convenient, Debian-like format.
-
D.
Fink
Fink is a British singer-songwriter and producer known for his atmospheric blend of folk, blues, and electronic music.
-
E.
FED
FED is the commonly used abbreviation for the Fluids Engineering Division, a professional group focused on research and advancements in fluid mechanics and related technologies.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
DNA-binding protein
ⓘ
RNA-binding motif protein ⓘ RNA-binding protein ⓘ nuclear protein ⓘ protein ⓘ |
| aggregationProperty | forms fibrillar aggregates ⓘ |
| alsoKnownAs |
TLS
ⓘ
translocated in liposarcoma ⓘ |
| associatedWithDisease |
ALS
ⓘ
surface form:
ALS type 6
FUS proteinopathy ⓘ amyotrophic lateral sclerosis ⓘ frontotemporal dementia ⓘ |
| biologicalProcess |
DNA repair
ⓘ
RNA metabolism ⓘ gene expression regulation ⓘ mRNA splicing via spliceosome ⓘ stress granule assembly ⓘ |
| cellularComponent |
nuclear speckle
ⓘ
stress granule ⓘ |
| chromosomalLocation | 16p11.2 ⓘ |
| containsDomain |
RGG-rich region
ⓘ
RNA-recognition motif ⓘ low-complexity prion-like domain ⓘ zinc finger domain ⓘ |
| encodedBy |
FUS
self-linksurface differs
ⓘ
surface form:
FUS gene
|
| fullName |
FUS
self-linksurface differs
ⓘ
surface form:
fused in sarcoma
|
| interactsWith |
EWSR1
ⓘ
RNA polymerase II ⓘ TAF15 ⓘ |
| involvedIn |
DNA damage response
ⓘ
alternative splicing regulation ⓘ microRNA processing ⓘ |
| localizationSignal |
nuclear export signal
ⓘ
nuclear localization signal ⓘ |
| molecularFunction |
DNA binding
ⓘ
RNA binding ⓘ RNA splicing regulation ⓘ RNA transport ⓘ mRNA processing ⓘ transcription regulation ⓘ |
| mutationEffect |
cytoplasmic mislocalization
ⓘ
pathological aggregation ⓘ |
| organism | Homo sapiens ⓘ |
| pathologyFeature | inclusion bodies in motor neurons ⓘ |
| postTranslationalModification |
arginine methylation
ⓘ
phosphorylation ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: FUS Description of subject: FUS is a DNA/RNA-binding protein whose mutations are implicated in neurodegenerative diseases, particularly certain forms of amyotrophic lateral sclerosis (ALS).
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.