RNA polymerase II
E561106
RNA polymerase II is the eukaryotic enzyme complex responsible for transcribing DNA into messenger RNA and many non-coding RNAs, playing a central role in gene expression.
Statements (71)
| Predicate | Object |
|---|---|
| instanceOf |
DNA-directed RNA polymerase
ⓘ
eukaryotic RNA polymerase ⓘ multi-subunit enzyme complex ⓘ |
| alsoKnownAs |
Pol II
NERFINISHED
ⓘ
RNAP II NERFINISHED ⓘ |
| belongsTo | RNA polymerase II transcription machinery ⓘ |
| binds |
promoter DNA
ⓘ
ribonucleoside triphosphates ⓘ template strand of DNA ⓘ |
| catalyzes | formation of phosphodiester bonds in RNA ⓘ |
| evolutionarilyRelatedTo |
archaeal RNA polymerase
ⓘ
bacterial RNA polymerase core enzyme ⓘ |
| hasConsensusSequence | YSPTSPS in CTD repeats ⓘ |
| hasEnzymeCommissionNumber | EC 2.7.7.6 ⓘ |
| hasFunction |
DNA-dependent RNA synthesis
ⓘ
capping of nascent RNA via CTD recruitment ⓘ coupling transcription with 3′ end processing ⓘ coupling transcription with RNA splicing ⓘ gene expression regulation ⓘ mRNA synthesis ⓘ |
| hasMolecularFeature | C-terminal domain heptad repeats ⓘ |
| hasPart |
C-terminal domain of Rpb1
ⓘ
Rpb1 subunit ⓘ Rpb10 subunit ⓘ Rpb11 subunit ⓘ Rpb12 subunit ⓘ Rpb2 subunit ⓘ Rpb3 subunit ⓘ Rpb4 subunit ⓘ Rpb5 subunit ⓘ Rpb6 subunit ⓘ Rpb7 subunit NERFINISHED ⓘ Rpb8 subunit ⓘ Rpb9 subunit NERFINISHED ⓘ |
| hasProcess |
promoter clearance
ⓘ
transcription elongation ⓘ transcription initiation ⓘ transcription termination ⓘ |
| hasRoleIn |
cell cycle–regulated transcription
ⓘ
developmental gene regulation ⓘ stress response gene expression ⓘ |
| interactsWith |
DSIF complex
ⓘ
Mediator complex NERFINISHED ⓘ NELF complex NERFINISHED ⓘ TFIIB NERFINISHED ⓘ TFIID NERFINISHED ⓘ TFIIE NERFINISHED ⓘ TFIIF NERFINISHED ⓘ TFIIH NERFINISHED ⓘ |
| isEncodedBy | multiple nuclear genes ⓘ |
| isEssentialFor | viability of most eukaryotic cells ⓘ |
| isInhibitedBy | alpha-amanitin ⓘ |
| isPresentIn |
animals
ⓘ
fungi ⓘ plants ⓘ protists ⓘ |
| isRegulatedBy |
CDK7 kinase
NERFINISHED
ⓘ
CDK9 kinase NERFINISHED ⓘ CTD phosphorylation ⓘ Mediator complex NERFINISHED ⓘ general transcription factors ⓘ transcriptional activators ⓘ transcriptional repressors ⓘ |
| isTargetOf | alpha-amanitin NERFINISHED ⓘ |
| occursIn |
archaeal cells (functional homologs)
ⓘ
eukaryotic nucleus ⓘ |
| transcribes |
long non-coding RNAs
ⓘ
many non-coding RNAs ⓘ messenger RNA ⓘ microRNA primary transcripts ⓘ small nuclear RNAs ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.