ALS
E24881
ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and ultimately respiratory failure.
Observed surface forms (2)
| Surface form | Occurrences |
|---|---|
| Lou Gehrig's disease | 2 |
| ALS foundations | 1 |
Statements (68)
| Predicate | Object |
|---|---|
| instanceOf |
motor neuron disease
ⓘ
neurodegenerative disease ⓘ progressive disease ⓘ |
| affects |
brain
ⓘ
lower motor neurons ⓘ spinal cord ⓘ upper motor neurons ⓘ voluntary muscles ⓘ |
| alsoKnownAs | Lou Gehrig's disease ⓘ |
| associatedWithGene |
C9orf72
ⓘ
FUS ⓘ SOD1 ⓘ TARDBP ⓘ |
| canBeAssociatedWith | frontotemporal dementia ⓘ |
| canLeadTo |
complete paralysis
ⓘ
death from respiratory failure ⓘ |
| causes |
muscle atrophy
ⓘ
muscle weakness ⓘ paralysis ⓘ respiratory failure ⓘ spasticity ⓘ |
| diagnosedBy |
clinical evaluation
ⓘ
electromyography ⓘ exclusion of other conditions ⓘ nerve conduction studies ⓘ |
| doesNotTypicallyAffect |
bladder control early in disease
ⓘ
sensory neurons ⓘ |
| fullName | amyotrophic lateral sclerosis ⓘ |
| hasCommonInitialPresentation |
asymmetric limb weakness
ⓘ
bulbar onset symptoms ⓘ |
| hasFamilialForm | familial ALS ⓘ |
| hasIncidence | about 1–2 per 100000 person-years ⓘ |
| hasMedianSurvival | 2–5 years after symptom onset ⓘ |
| hasNo | known cure ⓘ |
| hasPathology |
TDP-43 protein aggregates
ⓘ
corticospinal tract degeneration ⓘ degeneration of motor neurons ⓘ |
| hasPrevalence | about 4–6 per 100000 people ⓘ |
| hasRiskFactor |
certain genetic mutations
ⓘ
family history of ALS ⓘ male sex ⓘ older age ⓘ |
| hasSporadicForm | sporadic ALS ⓘ |
| hasSymptom |
difficulty walking
ⓘ
dysarthria ⓘ dysphagia ⓘ fasciculations ⓘ hand weakness ⓘ muscle cramps ⓘ shortness of breath ⓘ |
| hasTreatment |
edaravone
ⓘ
riluzole ⓘ supportive care ⓘ |
| hasTreatmentGoal |
maintain quality of life
ⓘ
slow disease progression ⓘ symptom management ⓘ |
| hasTypicalOnsetAge |
late adulthood
ⓘ
middle adulthood ⓘ |
| isClassifiedUnder |
335.20 (ICD-9-CM)
ⓘ
G12.21 (ICD-10) ⓘ G12.21 (ICD-10-CM) ⓘ |
| isRecognizedBy |
National Institute of Neurological Disorders and Stroke
ⓘ
World Health Organization ⓘ |
| isSubsetOf | motor neuron diseases ⓘ |
| isUsually | fatal ⓘ |
| moreCommonIn | males ⓘ |
| proportionFamilial | 5–10 percent of cases ⓘ |
| proportionSporadic | 90–95 percent of cases ⓘ |
Referenced by (8)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Lou Gehrig
subject surface form:
Lou Gehrig
this entity surface form:
Lou Gehrig's disease
this entity surface form:
Lou Gehrig's disease
this entity surface form:
ALS foundations