John Cunningham virus
E559471
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
All labels observed (1)
| Label | Occurrences |
|---|---|
| John Cunningham virus canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5981293 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: John Cunningham virus Context triple: [progressive multifocal leukoencephalopathy, hasPathogen, John Cunningham virus]
-
A.
EBV
EBV is the National Rail station code for Ebbw Vale Parkway railway station in Wales.
-
B.
Vircava
Vircava is a river in Latvia that serves as one of the tributaries feeding into the larger Lielupe River system.
-
C.
Ebolavirus
Ebolavirus is a genus of filamentous, enveloped RNA viruses in the Filoviridae family that cause severe and often fatal hemorrhagic fever in humans and other primates.
-
D.
CV-2
CV-2 refers to the Imperial Japanese Navy aircraft carrier Hiryū, a key fleet carrier that participated in major early Pacific War battles before being sunk at Midway in 1942.
-
E.
TMV
TMV is a deemed university in Pune, India, known for offering a wide range of undergraduate and postgraduate programs with an emphasis on Indian culture, philosophy, and social sciences.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: John Cunningham virus Target entity description: John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
A.
EBV
EBV is the National Rail station code for Ebbw Vale Parkway railway station in Wales.
-
B.
Vircava
Vircava is a river in Latvia that serves as one of the tributaries feeding into the larger Lielupe River system.
-
C.
Ebolavirus
Ebolavirus is a genus of filamentous, enveloped RNA viruses in the Filoviridae family that cause severe and often fatal hemorrhagic fever in humans and other primates.
-
D.
CV-2
CV-2 refers to the Imperial Japanese Navy aircraft carrier Hiryū, a key fleet carrier that participated in major early Pacific War battles before being sunk at Midway in 1942.
-
E.
TMV
TMV is a deemed university in Pune, India, known for offering a wide range of undergraduate and postgraduate programs with an emphasis on Indian culture, philosophy, and social sciences.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
DNA virus
ⓘ
human pathogen ⓘ non-enveloped virus ⓘ opportunistic virus ⓘ polyomavirus ⓘ |
| alsoKnownAs |
JC virus
NERFINISHED
ⓘ
JCV NERFINISHED ⓘ |
| BaltimoreClassification | Group I double-stranded DNA viruses ⓘ |
| capsidSymmetry | icosahedral ⓘ |
| causes | progressive multifocal leukoencephalopathy ⓘ |
| cellReceptor | serotonin receptor 5-HT2A (for some strains) ⓘ |
| diagnosisMethod |
PCR detection of viral DNA in cerebrospinal fluid
ⓘ
brain MRI showing multifocal white matter lesions ⓘ brain biopsy with viral inclusions ⓘ |
| diseaseType | demyelinating disease of the central nervous system ⓘ |
| enveloped | no ⓘ |
| family | Polyomaviridae NERFINISHED ⓘ |
| firstDescribed | 1971 ⓘ |
| genomeSize | approximately 5.1 kilobase pairs ⓘ |
| genomeType | circular double-stranded DNA ⓘ |
| genus | Betapolyomavirus NERFINISHED ⓘ |
| host | Homo sapiens ⓘ |
| infectionPattern | typically asymptomatic ⓘ |
| latencySite |
bone marrow
ⓘ
kidney ⓘ lymphoid tissues ⓘ |
| namedAfter | John Cunningham (patient in whom the virus was first identified) NERFINISHED ⓘ |
| oncogenicPotential | possible association with some tumors (not clearly established) ⓘ |
| pathogenesisFeature | lytic infection of oligodendrocytes leading to demyelination ⓘ |
| primaryTropism |
astrocytes
ⓘ
kidney epithelial cells ⓘ oligodendrocytes ⓘ |
| reactivationCondition |
AIDS
NERFINISHED
ⓘ
hematologic malignancy ⓘ immunosuppression ⓘ organ transplantation ⓘ treatment with natalizumab ⓘ treatment with other monoclonal antibodies affecting immunity ⓘ |
| riskGroup |
HIV-positive individuals with low CD4 counts
ⓘ
patients receiving immunosuppressive therapies ⓘ |
| seroprevalenceInAdults | 50–80 percent ⓘ |
| targetCellInPML | oligodendrocytes ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
likely respiratory
ⓘ
oral-fecal ⓘ possibly urine exposure ⓘ |
| treatment | restoration of immune function ⓘ |
| treatmentChallenge | no specific antiviral therapy with proven efficacy ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: John Cunningham virus Description of subject: John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.