BCRP

E241383

ATP-binding cassette transporter drug transporter efflux transporter membrane protein multidrug resistance protein

BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.

Try in SPARQL Jump to: Surface forms Statements Referenced by

All labels observed (6)

Label	Occurrences
ABCG2	1
ATP-binding cassette sub-family G member 2	1
ATP-binding cassette transporter family	1
BCRP canonical	1
Breast Cancer Resistance Protein	1
breast cancer resistance protein	1

Statements (52)

Predicate	Object
instanceOf	ATP-binding cassette transporter ⓘ drug transporter ⓘ efflux transporter ⓘ membrane protein ⓘ multidrug resistance protein ⓘ
alsoKnownAs	BCRP ⓘ surface form: ABCG2 BCRP ⓘ surface form: ATP-binding cassette sub-family G member 2 BCRP ⓘ surface form: Breast Cancer Resistance Protein
associatedWith	chemotherapy resistance ⓘ gout susceptibility via urate transport ⓘ reduced intracellular drug accumulation ⓘ
belongsToFamily	BCRP self-linksurface differs ⓘ surface form: ATP-binding cassette transporter family
belongsToSubfamily	ABC subfamily G ⓘ
biologicalRole	contribution to pharmacokinetic variability ⓘ efflux of drugs ⓘ efflux of xenobiotics ⓘ limitation of oral drug absorption ⓘ modulation of drug disposition ⓘ multidrug resistance in cancer cells ⓘ protection of tissues from toxic compounds ⓘ
containsDomain	nucleotide-binding domain ⓘ
effectOfPolymorphism	altered drug pharmacokinetics ⓘ altered transporter expression ⓘ
encodedBy	ABCG2 gene ⓘ
inhibitedBy	Ko143 ⓘ cyclosporine A ⓘ elacridar ⓘ tyrosine kinase inhibitors ⓘ
localization	apical membrane of epithelial cells ⓘ blood–brain barrier endothelial cells ⓘ hematopoietic stem cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental syncytiotrophoblast ⓘ plasma membrane ⓘ
organism	Homo sapiens ⓘ
polymorphism	ABCG2 c.421C>A (Q141K) ⓘ
structure	half-transporter requiring homodimerization ⓘ
substrateOf	estrone-3-sulfate ⓘ fluoroquinolone antibiotics ⓘ imatinib ⓘ irinotecan and its metabolites ⓘ methotrexate ⓘ mitoxantrone ⓘ rosuvastatin ⓘ sulfasalazine ⓘ topotecan ⓘ uric acid ⓘ
topology	six transmembrane helices per monomer ⓘ
transportMechanism	ATP-dependent efflux ⓘ
usesEnergyFrom	ATP hydrolysis ⓘ

Referenced by (6)

Full triples — surface form annotated when it differs from this entity's canonical label.

Xarelto → isSubstrateOf → BCRP ⓘ

BCRP → alsoKnownAs → BCRP ⓘ

this entity surface form: Breast Cancer Resistance Protein

BCRP → alsoKnownAs → BCRP ⓘ

this entity surface form: ABCG2

BCRP → alsoKnownAs → BCRP ⓘ

this entity surface form: ATP-binding cassette sub-family G member 2

BCRP → belongsToFamily → BCRP self-linksurface differs ⓘ

this entity surface form: ATP-binding cassette transporter family

apixaban → substrateOf → BCRP ⓘ

this entity surface form: breast cancer resistance protein