sulfasalazine

E852342

Sulfasalazine is an anti-inflammatory drug commonly used to treat rheumatoid arthritis and inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.

Try in SPARQL Jump to: Statements Referenced by

Statements (61)

Predicate Object
instanceOf anti-inflammatory drug
azo compound
disease-modifying antirheumatic drug
pharmaceutical drug
sulfonamide
hasATCCode A07EC01
M01CX01
hasBioavailability poor
hasCASNumber 599-79-1
hasCommonAdverseEffect headache
loss of appetite
nausea
rash
vomiting
hasComponent 5-aminosalicylic acid
sulfapyridine
hasContraindication porphyria
salicylate hypersensitivity
sulfonamide hypersensitivity
hasEliminationHalfLife 5–10 hours
hasExcretion biliary
renal
hasGenericName sulfasalazine
hasINN sulfasalazine
hasMechanismOfAction acts as immunomodulator
inhibits NF-κB activation
inhibits prostaglandin synthesis
modulates inflammatory cytokine production
hasMetabolism colonic bacterial azo-reduction
hepatic acetylation
hasMolarMass 398.39 g/mol
hasMolecularFormula C18H14N4O5S
hasPregnancyCategoryUS B (for inflammatory bowel disease)
B (for rheumatoid arthritis)
hasProteinBinding 99%
hasRouteOfAdministration oral
hasSeriousAdverseEffect Stevens–Johnson syndrome
agranulocytosis
hemolytic anemia
hepatotoxicity
hasTradeName Azulfidine NERFINISHED
Salazopyrin NERFINISHED
hasUSAN sulfasalazine
interactsWith digoxin
folic acid
warfarin NERFINISHED
isAvailableAs enteric-coated tablet
oral tablet
isListedOn WHO Model List of Essential Medicines NERFINISHED
isProdrugOf 5-aminosalicylic acid
sulfapyridine
mayCause reversible oligospermia
mayCauseDeficiencyOf folate
requiresMonitoring complete blood count
liver function tests
treats Crohn’s disease
ankylosing spondylitis
juvenile idiopathic arthritis
psoriatic arthritis
rheumatoid arthritis
ulcerative colitis

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

BCRP substrateOf sulfasalazine