sulfasalazine
E852342
anti-inflammatory drug
azo compound
disease-modifying antirheumatic drug
pharmaceutical drug
sulfonamide
Sulfasalazine is an anti-inflammatory drug commonly used to treat rheumatoid arthritis and inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.
All labels observed (1)
| Label | Occurrences |
|---|---|
| sulfasalazine canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10291881 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: sulfasalazine Context triple: [BCRP, substrateOf, sulfasalazine]
-
A.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
-
B.
Celebrex
Celebrex is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis.
-
C.
Kevzara
Kevzara is a prescription monoclonal antibody medication (sarilumab) used to treat adults with moderate to severe rheumatoid arthritis by targeting the interleukin-6 (IL-6) receptor.
-
D.
Remicade
Remicade is a widely used monoclonal antibody biologic (infliximab) prescribed to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
E.
Stelara
Stelara is a prescription biologic medication (ustekinumab) used to treat autoimmune conditions such as psoriasis, psoriatic arthritis, and Crohn’s disease by targeting specific immune system pathways.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: sulfasalazine Target entity description: Sulfasalazine is an anti-inflammatory drug commonly used to treat rheumatoid arthritis and inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.
-
A.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
-
B.
Celebrex
Celebrex is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis.
-
C.
Kevzara
Kevzara is a prescription monoclonal antibody medication (sarilumab) used to treat adults with moderate to severe rheumatoid arthritis by targeting the interleukin-6 (IL-6) receptor.
-
D.
Remicade
Remicade is a widely used monoclonal antibody biologic (infliximab) prescribed to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
E.
Stelara
Stelara is a prescription biologic medication (ustekinumab) used to treat autoimmune conditions such as psoriasis, psoriatic arthritis, and Crohn’s disease by targeting specific immune system pathways.
- F. None of above. chosen
Statements (61)
| Predicate | Object |
|---|---|
| instanceOf |
anti-inflammatory drug
ⓘ
azo compound ⓘ disease-modifying antirheumatic drug ⓘ pharmaceutical drug ⓘ sulfonamide ⓘ |
| hasATCCode |
A07EC01
ⓘ
M01CX01 ⓘ |
| hasBioavailability | poor ⓘ |
| hasCASNumber | 599-79-1 ⓘ |
| hasCommonAdverseEffect |
headache
ⓘ
loss of appetite ⓘ nausea ⓘ rash ⓘ vomiting ⓘ |
| hasComponent |
5-aminosalicylic acid
ⓘ
sulfapyridine ⓘ |
| hasContraindication |
porphyria
ⓘ
salicylate hypersensitivity ⓘ sulfonamide hypersensitivity ⓘ |
| hasEliminationHalfLife | 5–10 hours ⓘ |
| hasExcretion |
biliary
ⓘ
renal ⓘ |
| hasGenericName | sulfasalazine ⓘ |
| hasINN | sulfasalazine ⓘ |
| hasMechanismOfAction |
acts as immunomodulator
ⓘ
inhibits NF-κB activation ⓘ inhibits prostaglandin synthesis ⓘ modulates inflammatory cytokine production ⓘ |
| hasMetabolism |
colonic bacterial azo-reduction
ⓘ
hepatic acetylation ⓘ |
| hasMolarMass | 398.39 g/mol ⓘ |
| hasMolecularFormula | C18H14N4O5S ⓘ |
| hasPregnancyCategoryUS |
B (for inflammatory bowel disease)
ⓘ
B (for rheumatoid arthritis) ⓘ |
| hasProteinBinding | 99% ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasSeriousAdverseEffect |
Stevens–Johnson syndrome
ⓘ
agranulocytosis ⓘ hemolytic anemia ⓘ hepatotoxicity ⓘ |
| hasTradeName |
Azulfidine
NERFINISHED
ⓘ
Salazopyrin NERFINISHED ⓘ |
| hasUSAN | sulfasalazine ⓘ |
| interactsWith |
digoxin
ⓘ
folic acid ⓘ warfarin NERFINISHED ⓘ |
| isAvailableAs |
enteric-coated tablet
ⓘ
oral tablet ⓘ |
| isListedOn | WHO Model List of Essential Medicines NERFINISHED ⓘ |
| isProdrugOf |
5-aminosalicylic acid
ⓘ
sulfapyridine ⓘ |
| mayCause | reversible oligospermia ⓘ |
| mayCauseDeficiencyOf | folate ⓘ |
| requiresMonitoring |
complete blood count
ⓘ
liver function tests ⓘ |
| treats |
Crohn’s disease
ⓘ
ankylosing spondylitis ⓘ juvenile idiopathic arthritis ⓘ psoriatic arthritis ⓘ rheumatoid arthritis ⓘ ulcerative colitis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: sulfasalazine Description of subject: Sulfasalazine is an anti-inflammatory drug commonly used to treat rheumatoid arthritis and inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.