Ko143
E852343
Ko143 is a potent and selective small-molecule inhibitor of the breast cancer resistance protein (BCRP/ABCG2) efflux transporter used in research to study and overcome multidrug resistance.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Ko143 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10291886 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Ko143 Context triple: [BCRP, inhibitedBy, Ko143]
-
A.
K-14
K-14 is a state highway in Kansas that runs through Ellsworth County, serving as part of the regional transportation network in central Kansas.
-
B.
Koja
Koja is a coastal district in North Jakarta, Indonesia, known for its dense urban neighborhoods and proximity to the city’s port and industrial areas.
-
C.
K4
K4 is an alternative name for Gasherbrum II, one of the world’s fourteen 8,000-meter peaks located in the Karakoram range on the China–Pakistan border.
-
D.
Koza
Koza was the former name of what is now Okinawa City, a major urban center on Japan’s Okinawa Island known for its close historical ties to nearby U.S. military bases.
-
E.
Kö
Kö is the colloquial name for Königsallee, Düsseldorf’s famous luxury shopping boulevard known for its upscale boutiques and central canal.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Ko143 Target entity description: Ko143 is a potent and selective small-molecule inhibitor of the breast cancer resistance protein (BCRP/ABCG2) efflux transporter used in research to study and overcome multidrug resistance.
-
A.
K-14
K-14 is a state highway in Kansas that runs through Ellsworth County, serving as part of the regional transportation network in central Kansas.
-
B.
Koja
Koja is a coastal district in North Jakarta, Indonesia, known for its dense urban neighborhoods and proximity to the city’s port and industrial areas.
-
C.
K4
K4 is an alternative name for Gasherbrum II, one of the world’s fourteen 8,000-meter peaks located in the Karakoram range on the China–Pakistan border.
-
D.
Koza
Koza was the former name of what is now Okinawa City, a major urban center on Japan’s Okinawa Island known for its close historical ties to nearby U.S. military bases.
-
E.
Kö
Kö is the colloquial name for Königsallee, Düsseldorf’s famous luxury shopping boulevard known for its upscale boutiques and central canal.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
ABCG2 inhibitor
ⓘ
BCRP inhibitor ⓘ chemosensitizer ⓘ research chemical ⓘ small-molecule inhibitor ⓘ |
| affects | drug efflux mediated by BCRP ⓘ |
| associatedWith | multidrug resistance in oncology research ⓘ |
| discoveredAs | derivative of fungal toxin fumitremorgin C ⓘ |
| effect |
increases intracellular accumulation of BCRP substrates
ⓘ
reverses BCRP-mediated drug resistance ⓘ |
| fieldOfUse |
drug transport and disposition research
ⓘ
oncology research ⓘ pharmacology research ⓘ |
| hasAdvantage | reduced neurotoxicity compared with fumitremorgin C in preclinical studies ⓘ |
| hasProperty |
high potency against BCRP
ⓘ
high selectivity for BCRP over other ABC transporters ⓘ non-competitive BCRP inhibition (commonly reported) ⓘ |
| hasSynonym |
Ko 143
ⓘ
Ko-143 ⓘ |
| mechanismOfAction | inhibition of BCRP/ABCG2 efflux transporter activity ⓘ |
| roleInResearch |
positive control in BCRP inhibition assays
ⓘ
reference inhibitor in transporter selectivity panels ⓘ tool compound to validate BCRP involvement in drug transport ⓘ |
| selectivityProfile |
more selective for BCRP than for MRP1
ⓘ
more selective for BCRP than for P-glycoprotein ⓘ |
| speciesStudiedIn |
human-derived cell lines
ⓘ
mouse models ⓘ rat models ⓘ |
| targets |
ABCG2
NERFINISHED
ⓘ
BCRP NERFINISHED ⓘ breast cancer resistance protein NERFINISHED ⓘ |
| transportersComparedWith |
MRP1 (ABCC1)
NERFINISHED
ⓘ
P-glycoprotein (ABCB1) NERFINISHED ⓘ |
| usedFor |
in vitro transporter inhibition assays
ⓘ
in vivo transporter inhibition studies ⓘ overcoming multidrug resistance in cancer models ⓘ study of multidrug resistance mechanisms ⓘ |
| usedIn |
animal models of drug resistance
ⓘ
cancer cell line studies ⓘ transfected cell systems expressing ABCG2 ⓘ |
| usedTo |
assess drug–drug interaction risk via BCRP inhibition
ⓘ
characterize pharmacokinetics of BCRP substrates ⓘ |
| usedWith |
BCRP substrate chemotherapeutic agents
ⓘ
SN-38 ⓘ mitoxantrone NERFINISHED ⓘ topotecan NERFINISHED ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Ko143 Description of subject: Ko143 is a potent and selective small-molecule inhibitor of the breast cancer resistance protein (BCRP/ABCG2) efflux transporter used in research to study and overcome multidrug resistance.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.